近红外光谱法快速鉴别伪品立普妥方法的研究  

Study on rapid identification of fake Lipitor by near-infrared consistency model

作　　者：赵玉泉 韩吴琦 张峰 李习莹 谢晓燕 Zhao Yuquan;Han Wuqi;Zhang Feng;Li Xiying;Xie Xiaoyan(Kaifeng Center for Food and Drug Control,Kaifeng 475000,China)

机构地区：[1]开封市食品药品检验所,开封475000

出　　处：《分析仪器》2023年第5期65-69,共5页Analytical Instrumentation

基　　金：河南省市场监督管理局科技计划项目,项目编号:2020sj52。

摘　　要：目的:建立近红外一致性模型用于快速鉴别伪品立普妥。方法:采集5个厂家的阿托伐他汀钙制剂在12000 cm^(-1)~4000 cm^(-1)范围的光谱,用一阶导数结合矢量归一化预处理光谱,采用偏最小二乘判别分析法(PLSDA)方法建立近红外一致性模型。结果:建立的一致性模型可以快速筛出伪品立普妥,结果与高效液相色谱法一致,准确率100%。结论:本研究建立的近红外一致性模型可用于伪品立普妥的快速筛查,并且操作简便,经济环保,有利于市场监管的提高市场监管的时效性,可推广应用。The near-infrared consistency model of atorvastatin calcium tablets was established.The spectra of atorvastain calcium tablets from 5 manufacturers were respectively scanned in the range of 12000 cm^(-1)—4000 cm^(-1).The original spectrum was pretreated by the first derivative combined with vector normalization method,and PLSDA method was used to establish the near-infrared consistency model.Through the model,the fake Lipitor can be quickly identified,and the results are consistent with that of HPLC,with an accuracy of 100%.This model is easy to operate,economical and environmentally friendly.

关 键 词：近红外光谱 一致性模型 快速鉴别 立普妥 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.33[化学工程—制药化工]