缺氧在骨质疏松与骨稳态中作用的研究进展  

Research Progress on the Role of Hypoxia in Osteoporosis and Bone Homeostasis

作　　者：范晓霞[1,2] 姚勇利[2] 蔡春梅[1] 格日力 FAN Xiao-Xia;YAO Yong-Li;CAI Chun-Mei;GE Ri-Li(Research Center for High Altitude Medicine,Key Laboratory of Ministry of Education for High Altitude Medicine,Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province(Qinghai-Utah Joint Research Key Lab for High Altitude Medicine),Laboratory for High Altitude Medicine of Qinghai Province;Qinghai Provincial People's Hospital,Xining 810001,China)

机构地区：[1]青海大学高原医学研究中心,高原医学教育部重点实验室,青海省高原医学应用基础重点实验室(青海-犹他高原医学联合重点实验室),青海省高原医学实验室 [2]青海省人民医院,西宁810001

出　　处：《生理科学进展》2023年第5期403-408,共6页Progress in Physiological Sciences

基　　金：国家自然科学基金(82072107,81960292);高原医学教育部重点实验室[青海省高原医学应用基础重点实验室(青海-犹他高原医学联合重点实验室)](2022-KF-05)资助课题。

摘　　要：骨骼对于支持肌肉和保护重要器官至关重要,也是钙和磷的储存池。骨骼是人体代谢最活跃的组织之一,其不断更新以适应健康所需。为了维持正常的骨骼相关细胞的生理功能,需要足够的氧气,因为有证据表明缺氧可能影响骨骼健康。低氧与骨质疏松形成之间的关系一直是近年热点研究话题。低氧在骨组织各细胞增殖、分化、凋亡及保持稳定等多方面扮演重要角色,深度参与骨重塑过程。本文在现有的相关文献报告基础上,对低氧与骨稳态、骨质疏松症的关系进行综述,以期对骨质疏松的防治提供参考。Bone is essential for supporting muscles and protecting vital organs,as well as serving as a reservoir for calcium and phosphorus.As one of the most metabolically active tissues in the body,bone undergoes constant remodeling to meet the demands of health.Adequate oxygen is required to maintain the physiological functions of bone cells,as evidence suggests that hypoxia may affect bone health.The relationship between hypoxia and osteoporosis has become a recent hot topic in research.Hypoxia plays a critical role in various aspects of bone tissue,including cell proliferation,differentiation,apoptosis,and maintenance of stability,and is deeply involved in bone remodeling.This article reviews the existing reports on the relationship between hypoxia and bone homeostasis,as well as osteoporosis,with the aim of providing a reference for future prevention and treatment of osteoporosis.

关 键 词：缺氧 骨质疏松 骨髓间充质细胞 成骨细胞 破骨细胞 

分 类 号：R336[医药卫生—人体生理学]