国产uMI 780型PET/CT仪^(18)F-FDG最适图像采集及处理条件探讨  

Discussion on the optimal acquisition and reconstruction protocol of uMI780 PET/CT by using^(18)F-FDG

作　　者：孙震[1] 赵燕燕[2] 毛旻航 王丽丽 张晓莹[1] 王惠煜 吴玉涛 顾思芸 刘士涛 董筠 钱政 庄橙 陈涛[1] SUN Zhen;ZHAO Yanyan;MAO Minhang;WANG Lili;ZHANG Xiaoying;WANG Huiyu;WU Yutao;GU Siyun;LIU Shitao;DONG Yun;QIAN Zheng;ZHUANG Cheng;CHEN Tao(Department of Nuclear Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Medical Equipment,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai United Imaging Healthcare Co.,Ltd.,Shanghai 201807,China)

机构地区：[1]上海中医药大学附属曙光医院核医学科,上海201203 [2]上海中医药大学附属曙光医院医学装备处,上海201203 [3]上海联影医疗科技有限公司,上海201807

出　　处：《肿瘤影像学》2023年第5期453-460,共8页Oncoradiology

摘　　要：目的:探讨国产uMI 780型正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)仪在临床应用^(18)F-FDG进行全身(脑部+体部)显像时的最佳图像采集及处理条件。方法:收集2017年8月—2018年5月符合要求的受试者400例,将400例患者随机纳入预先制订的由^(18)F-FDG注射量2.96 MBq/kg和3.70 MBq/kg、脑部PET显像时间3 min和2 min、体部2 min/床位和1.5 min/床位三者组合形成的4组(A1、A2、B1、B2,每组100例)研究序列。按照优(3分)、良(2分)、差(1分)对脑部和体部PET图像的代谢分布清晰度、设备性伪影、图像均匀性进行视觉评价,比较^(18)F-FDG注射量、显像时间和重建算法或重建参数组合对脑部和体部PET图像质量的影响。结果:脑部PET图像质量有序子集最大期望值法(ordered subset expectation maximization,OSEM)均明显优于滤波反投影法(filtered back projection,FBP)(P<0.001),而不同^(18)F-FDG注射量及显像时间组间差异无统计学意义。当^(18)F-FDG注射量为2.96 MBq/kg时,体部PET显像时间2 min/床位的代谢分布、图像均匀性均明显优于1.5 min/床位(P<0.05),而设备性伪影两者差异无统计学意义;当注射量为3.70 MBq/kg时,显像时间2 min/床位和1.5 min/床位间图像质量差异无统计学意义;当显像时间为2 min/床位时,注射量3.70 MBq/kg和2.96 MBq/kg间的图像质量差异无统计学意义;当显像时间为1.5 min/床位时,注射量3.70 MBq/kg在代谢分布和图像均匀性上呈现比注射量2.96 MBq/kg更好的趋势;应用OSEM算法重建体部PET图像时,迭代2次的代谢分布和图像均匀性明显优于迭代3次(P<0.01),而对设备性伪影无显著影响;高斯半高宽(full width at half maximum,FWHM)为4 mm的代谢分布和图像均匀性明显优于3 mm的图像(P<0.01),而图像设备性伪影仅个别组别呈现4 mm明显优于3 mm的图像(P<0.01)。结论:研究得出国产uMI 780型PET/CT仪临床应用^(18)F-FDG的最�Objective:To investigate the optimal acquisition and reconstruction protocol of uMI780 positron emission tomography(PET)/computed tomography(CT)in the clinical application of^(18)F-FDG for whole-body(head+body)imaging.Methods:A total of 400 subjects from August 2017 to May 2018 were collected.The 400 subjects were applied with two levels of FDG injection dose,3 or 2 min for brain scan,2 or 1.5 min/bed for body scan,OSEM and FBP resulted brain images,and 2-or 3-iteration OSEM body images with two Gaussian kernel for post-smoothing.Image quality was evaluated qualitatively and quantitatively and scored by two clinical physicians.Results:The OSEM image quality was significantly better than that FBP(P<0.001),but there was no significant difference in brain PET image quality between different injection doses or different scan times.When the injection doses of^(18)F-FDG was injected with 2.96 MBq/kg,image quality of body PET imaging with 2 min/bed were significantly better than the 1.5 min/bed(P<0.05);but,when the injection was 3.70 MBq/kg,there was no difference in image quality of body between 2 and 1.5 min/bed.When scan time was 2 min/bed,there was no significant difference in between image qualities of using 3.70 MBq/kg and 2.96 MBq/kg;but for 1.5 min/bed,the image quality of 3.70 MBq/kg was better than 2.96 MBq/kg.Two-iteration OSEM image quality of body were significantly better than that of 3 iterations(P<0.01).Image quality by using 4 mm FWHM Gaussian was significantly better than 3 mm Gaussian(P<0.01).Conclusion:By the study,we could obtain two optimal image and reconstruction protocols of^(18)F-FDG for uMI780 PET/CT in clinical application:①2.96 MBq/kg injection dose;2 min brain scan,2 min/bed body scan with 2-iteration OSEM reconstruction with 4 mm Gaussian smoothing;②3.70 MBq/kg injection dose;2 min brain scan,1.5 min/bed body scan with 2-iteration OSEM reconstruction with 4 mm Gaussian smoothing.

关 键 词：正电子发射体层成像/计算机体层成像 图像重建 ^(18)F-FDG 

分 类 号：R445.6[医药卫生—影像医学与核医学]