面向重大需求 引领学科前沿——“脂代谢可塑性调控的分子与细胞机制”重大项目结题综述  

Summary of the Achievements of Major Program on“Molecular and Cellular Mechanisms of Regulating Lipid Metabolic Plasticity”

作　　者：宋婀莉 王璞玥[1] 田艳艳[1] 殷文璇[2] 徐岩英[1] Eli Song;Puyue Wang;Yanyan Tian;Wenxuan Yin;Yanying Xu(Department of Life Sciences,National Natural Science Foundation of China,Beijing 100085;Bureau of International Cooperation,National Natural Science Foundation of China,Beijing 100085)

机构地区：[1]国家自然科学基金委员会生命科学部,北京100085 [2]国家自然科学基金委员会国际合作局,北京100085

出　　处：《中国科学基金》2023年第4期648-655,共8页Bulletin of National Natural Science Foundation of China

摘　　要：国家自然科学基金重大项目“脂代谢可塑性调控的分子与细胞机制”围绕脂代谢可塑性调控的分子与细胞机制这一生理学重大基础科学问题,在分子、细胞和组织器官水平上系统开展研究。阐释了脂代谢可塑性调控过程中感应脂肪酸、葡萄糖和氨基酸等营养物和代谢物的分子机制,揭示了细胞内不同细胞器的形态变化、互作交流和应激响应等在维持脂代谢稳态中的作用机制,发现了多种内分泌因子通过组织器官间交流互作参与机体脂代谢可塑性及其相关生理和病理生理学过程的调控机制。研究结果为肥胖、糖尿病等重大代谢性疾病的临床研究提供了新的理论依据,为我国代谢研究领域培养了一批优秀人才,使我国科学家在国际相关领域的研究中发挥了引领作用。最后,本文概述了脂代谢领域的发展态势以及下一步发展的建议。Focusing on the molecular and cellular mechanism of lipid metabolic plasticity,a key scientific question in the physiological field,the program carried out systematic research at the molecular,cellular,and tissue levels on three topics:the sensing mechanisms and functions in the plasticity of lipid metabolism;the key organelles implicated in lipid metabolic plasticity and their regulatory mechanisms;and the functions and mechanisms of novel endocrine factors in lipid metabolic plasticity.After 5 years of in-depth and meticulous research,the program obtained a series of novel findings.First,it elucidated a variety of novel sensing mechanisms for fatty acids,glucose,amino acids and other metabolites.Second,it clarified the functions of the organelles(endoplasmic reticulum,lipid droplets,mitochondria,lysosomes,etc.)involved in maintaining lipid homeostasis via morphological changes,communications,and stress responses.Third,it identified novel endocrine factors and characterized their regulatory functions in lipid metabolic plasticity and other biological processes.These results provide a valuable basis for the treatment of obesity,diabetes,and related major metabolic diseases.The program trained a group of outstanding scientists majoring in metabolism and physiology.These achievements make Chinese scientists and research play a leading role in the international metabolism society.Finally,we summary the current progress and future perspectives on lipid metabolism.

关 键 词：重大项目 脂质代谢 代谢可塑性 分子细胞机制 成果总结 

分 类 号：Q591.5[生物学—生物化学]