洋川芎内酯类化合物药理活性研究进展  

Research progress on the pharmacological activities of senkyunolides

作　　者：李青泉 万建波[2] 赵璐 Qingquan Li;Jian-Bo Wan;Lu Zhao(Pharmaceutical Informatics Institute,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,China;State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Taipa,Macao,China)

机构地区：[1]浙江大学药学院药物信息学研究所 [2]澳门大学中华医药研究院中药质量研究国家重点实验室,中国澳门

出　　处：《Acupuncture and Herbal Medicine》2023年第3期180-188,共9页针灸和草药（英文）

基　　金：This study was supported by the Zhejiang Provincial Natural Science Foundation of China(grant numbers LR23H280001 and LGF21H280005).

摘　　要：洋川芎内酯类化合物广泛存在于川芎等伞形科植物中,为一组苯酞类物质。川芎作为传统中药常用来治疗冠心病、偏头痛和风湿,现代药理学研究表明川芎中洋川芎内酯具有抗炎镇痛及心血管保护作用。近年来多项研究发现洋川芎内酯类化合物还具有抗菌、抗骨质疏松和抗纤维化等新药理作用,提示该类化合物生物学活性丰富。此外,多种洋川芎内酯生物利用度高且易于透过血脑屏障,包括洋川芎内酯I在内的一系列化合物可能用于治疗脑部疾病。洋川芎内酯的作用机制可能包括其对toll样受体4/核因子-κB、细胞外信号调节激酶、p38丝裂源活化蛋白激酶和c-Jun N-末端激酶等多条信号通路的调控作用。本综述回顾了洋川芎内酯药代动力学及药理活性的近期研究进展。该类化合物有望作为候选药物用于治疗多种疾病,具有重要临床价值。Senkyunolides are a group of phthalide molecules that exist in Umbelliferae plants,with the highest abundance in Ligusticum chuanxiong Hort,a medicinal herb with therapeutic applications in various diseases such as coronary heart disease,migraine,and rheumatism.Modern research has highlighted the anti-inflammatory,analgesic,and cardiovascular-protective properties of senkyunolides.Recently,some novel effects,such as antibacterial,anti-osteoporosis,and anti-fibrosis,have been reported for senkyunolides,indicating their diverse biological activities.In addition,because of its high bioavailability and ability to cross the blood-brain barrier(BBB),particularly exemplified by senkyunolide I(SEI),holds promise for the treatment of brain diseases.Multiple signaling pathways have been related to the pharmacological activities of senkyunolides,such as the toll-like receptor 4/nuclear factor-kappa B(NF-κB)signaling,extracellular signal–regulated kinase(ERK)pathway,p38 mitogen-activated protein kinase,and c-Jun N-terminal kinase(JNK)pathways.Here,we review the research progress on the pharmacokinetics and pharmacological effects of senkyunolides,which are promising candidates for future drug development and have significant clinical value in the treatment of various diseases.

关 键 词：川芎 药代动力学 药理活性 洋川芎内酯 

分 类 号：R285[医药卫生—中药学]