生物4D打印技术在心血管组织工程中的研究及应用进展  

4D bioprinting technology and its application in cardiovascular tissue engineering

作　　者：黄宇翔 李琪 叶武 黄子鸣 秦涵潇 赵明[2] 刘明[2] HUANG Yuxiang;LI Qi;YE Wu;HUANG Ziming;QIN Hanxiao;ZHAO Ming;LIU Ming(College of Materials Science and Engineering,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China;The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou 310022,Zhejiang,China;School of Molecular Medicine,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,Zhejiang,China)

机构地区：[1]浙江工业大学材料科学与工程学院,浙江杭州310014 [2]中国科学院基础医学与肿瘤研究所、中国科学院大学附属肿瘤医院(浙江省肿瘤医院),浙江杭州310022 [3]中国科学院大学杭州高等研究院分子医学院,浙江杭州310024

出　　处：《生物工程学报》2023年第10期4046-4056,共11页Chinese Journal of Biotechnology

基　　金：浙江省自然科学基金重点项目(LZ22A020005)。

摘　　要：3D生物打印技术是应用包含生物材料与活细胞在内的生物墨水来构造生物医学产品的技术,近年来得到快速发展。3D打印的组织是静态的,而人体的组织则处于实时动态之中,并且随时能够发生形态及性能的变化,要提高体外环境与体内真实环境的吻合度,就需要一种能够模拟这种动态过程的体外组织构建技术。4D打印概念的提出,给实现这种复杂技术提供了一条新的思路。4D打印可理解为“3D打印+时间”,在3D打印基础上,4D打印应用一种或多种对刺激具有响应的智能材料,这种材料可以在相应的刺激下改变它们的形态、性能及功能,以满足多种需求。本文重点关注4D打印技术在心血管系统中的最新研究进展及其潜在应用领域,为该项技术的发展提供一些理论及应用参考价值。3D bioprinting technology is a rapidly developing technique that employs bioinks containing biological materials and living cells to construct biomedical products.However,3D-printed tissues are static,while human tissues are in real-time dynamic states that can change in morphology and performance.To improve the compatibility between in vitro and in vivo environments,an in vitro tissue engineering technique that simulates this dynamic process is required.The concept of 4D printing,which combines“3D printing+time”provides a new approach to achieving this complex technique.4D printing involves applying one or more smart materials that respond to stimuli,enabling them to change their shape,performance,and function under the corresponding stimulus to meet various needs.This article focuses on the latest research progress and potential application areas of 4D printing technology in the cardiovascular system,providing a theoretical and practical reference for the development of this technology.

关 键 词：4D生物打印 心血管组织 再生医学 生物医疗 智能材料 

分 类 号：R318[医药卫生—生物医学工程] TP391.73[医药卫生—基础医学]