空间环境下肠道菌群失调的研究进展  

Gut microbial dysbiosis under space environment:a review

作　　者：张瀚文 刘秀云[2] 武睿鹏 李玉娟[1] ZHANG Hanwen;LIU Xiuyun;WU Ruipeng;LI Yujuan(School of Life Science,Beijing Institute of Technology,Beijing 100081,China;Beiqing Road Clinic,Chinese PLA General Hospital Jingbei Medical Area,Beijing 100094,China)

机构地区：[1]北京理工大学生命学院,北京100081 [2]解放军总医院京北医疗区北清路门诊部,北京100094

出　　处：《生物工程学报》2023年第10期4075-4084,共10页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(81973572);航天员健康中心重点实验室研究基金(AHCC2021KF004)。

摘　　要：空间环境中的特殊因素会导致航天员肠道菌群及其代谢产物的失调,对机体会产生系统性的生理影响。本文综述了近年来太空飞行/模拟空间环境对肠道菌群及其代谢产物影响的研究进展。太空飞行/模拟空间环境(space flight/simulated space environment,SF/SPE)可导致侵袭性致病菌的增多及有益菌的减少,肠道炎症加剧与通透性增加,也会引起菌群的有益代谢物减少或有害代谢物增加,进而导致机体内代谢的紊乱,或可诱发其他系统的损伤,从而不利于航天员的健康与工作效率。总结太空飞行/模拟空间环境对肠道菌群产生的影响,可为该领域的后续研究与航天员的在轨健康防护提供科学依据。Unique factors in the space environment can cause dysbiosis of astronauts’gut microbiota and its metabolites,which may exert systematic physiological effects on human body.Recent progress regarding the effect of space flight/simulated space environment(SF/SPE)on the composition of gut microbiota and its metabolites was reviewed in this paper.SF/SPE may cause the increase of invasive pathogenic bacteria and the decrease of beneficial bacteria,aggravating intestinal inflammation and increasing intestinal permeability.SF/SPE may also cause the decrease of beneficial metabolites or the increase of harmful metabolites of gut microbiota,leading to metabolism disorder in vivo,or inducing damage of other systems,thus not beneficial to the health and working efficiency of astronauts.Summarizing the effects of SF/SPE on gut microbiota may provide scientific basis for further researches in this field and the on-orbit health protection of astronauts.

关 键 词：太空飞行 模拟空间环境 肠道菌群 代谢产物 

分 类 号：R852[医药卫生—航空、航天与航海医学]