轴突生长抑制因子蛋白的生物学功能和作用研究进展  

Advance in biological functions and roles of neurite outgrowth inhibitor proteins

作　　者：张艳 徐浩森[1,2] 蒋欢 兰金意 杨单植 刘沛敏 白晓燕 ZHANG Yan;XU Hao-sen;JIANG Huan;LAN Jin-yi;YANG Shan-zhi;LIU Pei-min;BAI Xiao-yan(The First School of Clinical Medicine,Guangdong Medical University,Zhanjiang 524023,China;Department of Nephrology,Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Guangzhou 510080,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524023 [2]南方医科大学附属广东省人民医院(广东省医学科学院)肾内科,广东广州510080

出　　处：《广东医科大学学报》2023年第5期574-578,共5页Journal of Guangdong Medical University

基　　金：国家自然科学基金面上项目(82170730,81873616)。

摘　　要：近年来,一系列研究发现轴突生长抑制因子(Nogo)蛋白在多种疾病中发挥重要作用。此外,Nogo还通过介导巨噬细胞M1/M2极化参与炎症进程。该文综述了Nogo家族在疾病中的作用并揭示其分子机制。In recent years,a series of studies have found that neurite outgrowth inhibitor(Nogo) proteins play an important role in a variety of diseases.In addition,Nogo is actively involved in the inflammatory process by mediating M1/M2polarization of macrophages.This paper reviewed the role of Nogo family in diseases and revealed its molecular mechanism.

关 键 词：轴突生长抑制因子 肾脏疾病 心血管疾病 肝脏疾病 巨噬细胞 

分 类 号：R338[医药卫生—人体生理学]