贝前列素钠片治疗脑小血管病患者临床研究  

Clinical Study on Beraprost Sodium Tablets in Treating Patients with Cerebral Small Vessel Diseases

作　　者：曾伟 夏峰[1] Zeng Wei;Xia Feng(Shangshui County People's Hospital,Zhoukou 460010,Henan Province,China)

机构地区：[1]河南省周口市商水县人民医院神经内科,河南周口460010

出　　处：《罕少疾病杂志》2023年第10期15-17,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的研究贝前列素钠片治疗脑小血管病患者的影响。方法选取河南省周口市商水县人民医院神经内科自2019年11月至2020年11月收治的92例脑小血管病患者进行前瞻性研究。采用抛硬币法将其等分为两组:对照组(n=46)和观察组(n=46)均接受常规治疗,观察组另外加用贝前列素钠片治疗。对比两组患者认知功能,血清指标,血流速度及并发症发生率。结果治疗后观察组MMSE、ADL、MOCA评分分别为(26.12±4.45)分、(73.01±6.21)分(23.01±3.51)分,高于对照组,差异有统计学意义(t=2.427、2.934、2.446,P<0.05)。治疗后观察组Hcy、NSE水平分别为(9.24±2.01)μmol/L、(17.23±2.36)mg/L,低于对照组;NGB水平为(6.25±1.03)μg/L,高于对照组,差异有统计学意义(t=3.008、3.258、2.128,P<0.05)。治疗后观察组基底动脉以及右、左侧椎动脉血流速度分别为(48.25±5.07)cm/s、(45.94±4.50)cm/s、(46.15±3.28)cm/s,快于对照组,差异有统计学意义(t=2.924、3.023、2.713,P<0.05);两组不良反应比较无明显区别(χ^(2)=1.392,P=0.238)。结论贝前列素钠片有助促进患者血流循环恢复,提高神经认知功能,治疗脑小血管病安全有效。Objective To study the effect of beprost sodium tablets on patients with cerebrovascular disease.Methods A prospective study was conducted on 92 patients with cerebrovascular diseases treated in the Department of Neurology of Shangshui County People's Hospital,Zhoukou City,Henan Province from November 2019 to November 2020.They were equally divided into two groups by coin tossing method:the control group(n=46)and the observation group(n=46)received routine treatment,and the observation group was treated with beprost sodium tablets.The cognitive function,serum indexes,blood flow velocity and the incidence of complications were compared between the two groups.Results After treatment,the scores of MMSE,ADL and MOCA in the observation group were(26.12±4.45)and(73.01±6.21)respectively(23.01±3.51),which were higher than those in the control group(t=2.427,2.934,2.446,P<0.05).After treatment,the levels of Hcy and NSE in the observation group were(9.24±2.01)μmol/l and(17.23±2.36)mg/l respectively,lower than those in the control group;Ngb level was(6.25±1.03)μg/l,which was higher than that of the control group,and the difference was statistically significant(t=3.008,3.258,2.128,P<0.05).After treatment,the blood flow velocity of basilar artery and right and left vertebral artery in the observation group were(48.25±5.07)cm/s,(45.94±4.50)cm/s and(46.15±3.28)cm/s respectively,which was faster than that in the control group,and the difference was statistically significant(t=2.924,3.023,2.713,P<0.05);There was no significant difference in adverse reactions between the two groups(χ^(2)=1.392,P=0.238).Conclusion Beraprost sodium tablets can promote the recovery of blood circulation,improve the neurocognitive function,and is safe and effective in the treatment of cerebral small vessel disease.

关 键 词：贝前列素钠 脑小血管病 认知功能 血浆水平 

分 类 号：R541.9[医药卫生—心血管疾病]