益肾活血汤联合阿司匹林治疗产科抗磷脂综合征的临床研究  

Clinical Study of Yishen Huoxue Decoction Combined with Aspirin in the Treatment of Obstetric Antiphospholipid Syndrome

作　　者：范媛媛 冯骐 FAN Yuanyuan;FENG Qi(Hai’an Hospital of Traditional Chinese Medicine,Jiangsu Province,Hai’an 226600,China;不详)

机构地区：[1]江苏省海安市中医院,江苏海安226600

出　　处：《中国医学创新》2023年第29期60-64,共5页Medical Innovation of China

摘　　要：目的:探究益肾活血汤联合阿司匹林治疗产科抗磷脂综合征(OAPS)的临床效果。方法:选取海安市中医院妇产科2020年2月—2022年2月收治的110例OAPS患者作为本次研究对象,采用电脑随机数字表法将其分为对照组和研究组,每组55例。对照组患者予以阿司匹林治疗,研究组在对照组基础上增加益肾活血汤治疗。比较两组患者血清抗体水平、血清激素水平、凝血功能、妊娠结局、不良事件及药物不良反应发生情况。结果:治疗前,两组抗心磷脂抗体-免疫球蛋白G(ACA-IgG)、狼疮抗凝物(LA)及抗β_(2)糖蛋白Ⅰ抗体-Ig G(β_(2)-GPⅠ-Ig G)比较,差异均无统计学意义(P>0.05);治疗后,两组ACA-Ig G、β_(2)-GPⅠ-Ig G水平较治疗前均明显下降,研究组均明显低于对照组,LA较治疗前均明显缩短,研究组短于对照组(P<0.05)。治疗前,两组人绒毛膜促性腺激素(h CG)、孕酮(P)水平比较,差异均无统计学意义(P>0.05);治疗后,两组h CG水平较治疗前下降,P水平较治疗前均明显上升(P<0.05),研究组h CG、P均高于对照组(P<0.05)。治疗前,两组D-二聚体(D-D)、凝血酶原时间(PT)、血小板聚集率(PAR)比较,差异均无统计学意义(P>0.05);治疗后,两组D-D、PAR水平较治疗前均明显下降(P<0.05),研究组均明显低于对照组(P<0.05),PT较治疗前均明显延长(P<0.05),研究组明显长于对照组(P<0.05)。研究组妊娠成功率明显高于对照组(P<0.05),不良事件发生率明显低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益肾活血汤联合阿司匹林治疗OAPS可明显降低相关抗体水平,控制病情发展,并可改善孕激素水平及凝血功能,改善妊娠结局,且用药较为安全。Objective:To investigate the clinical effect of Yishen Huoxue Decoction combined with Aspirin in the treatment of obstetric antiphospholipid syndrome(OAPS).Method:A total of 110 OAPS patients admitted to the Obstetrics and Gynecology Department of Hai’an Hospital of Traditional Chinese Medicine from February 2020 to February 2022 were selected as the subjects of this study,and were divided into control group and study group according to computer random number method,with 55 cases in each group.The control group was treated with Aspirin,and the study group was treated with Yishen Huoxue Decoction on the basis of the control group.Serum antibody levels,serum hormone levels,coagulation function,pregnancy outcome and the occurrence of adverse events and adverse drug reactions were compared between the two groups.Result:Before treatment,there were no significant differences in anticardiolipin antibody-immunoglobulin G(ACA-IgG),lupus anticoagulant(LA)and anti-β_(2) glycoproteinⅠantibody-IgG(β_(2)-GPⅠ-IgG)between two groups(P>0.05).After treatment,the levels of ACA-IgG and β_(2)-GPⅠ-IgG in both groups were significantly decreased compared with those before treatment,and those in the study group were significantly lower than those in the control group,and the LA were significantly shorter compared with those before treatment,and that in the study group was significantly shorter than that in the control group(P<0.05).Before treatment,there were no significant differences in the levels of human chorionic gonadotrophin(hCG)and progesterone(P)between two groups(P>0.05).After treatment,the hCG level in both groups decreased,and the P level increased significantly(P<0.05),the hCG and P in the study group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in D-dimer(D-D),prothrombin time(PT)and platelet aggregation rate(PAR)between two groups(P>0.05).After treatment,the levels of D-D and PAR in both groups were significantly lower than those before treatment(P<0

关 键 词：产科抗磷脂综合征 益肾活血汤 阿司匹林 凝血功能 妊娠结局 

分 类 号：R593.2[医药卫生—内科学]