腺苷蛋氨酸联合还原型谷胱甘肽治疗病毒性肝炎患者的效果  

Efficacy of Ademetionine Combined with Reduced Glutathione in the Treatment of Patients with Viral Hepatitis

作　　者：徐平平 周志云 邓红苗 XU Pingping;ZHOU Zhiyun;DENG Hongmiao(Yingtan City People's Hospital,Jiangxi Province,Yingtan 335000,China;不详)

机构地区：[1]江西省鹰潭市人民医院,江西鹰潭335000

出　　处：《中国医学创新》2023年第29期73-76,共4页Medical Innovation of China

摘　　要：目的:探讨腺苷蛋氨酸联合还原型谷胱甘肽治疗病毒性肝炎患者的效果及对肝功能指标的影响。方法:选取鹰潭市人民医院2018年1月—2022年6月收治的病毒性肝炎患者100例,按照简单随机化法分为对比组与联合组,各50例。所有患者均采取对症治疗,同时对比组予以还原型谷胱甘肽治疗,联合组予以腺苷蛋氨酸联合还原型谷胱甘肽治疗,所有患者均连续治疗4周。比较治疗后两组患者临床效果,比较治疗前后两组患者肝功能指标[谷丙转氨酶(ALT)、总胆红素(TBIL)、谷草转氨酶(AST)]、炎症指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)]变化。结果:治疗后,联合组临床效果优于对比组,总有效率高于对比组(P<0.05);两组治疗后ALT、TBIL、AST、CRP、IL-6、TNF-α、MDA水平较治疗前均降低(P<0.05),且联合组均低于对比组(P<0.05);两组治疗后GSH-Px、SOD水平较治疗前均上升(P<0.05),且联合组均高于对比组(P<0.05)。结论:腺苷蛋氨酸联合还原型谷胱甘肽治疗病毒性肝炎能显著提高临床效果,改善肝功能,减轻炎症与氧化应激反应。Objective:To explore the efficacy of Ademetionine combined with Reduced Glutathione in the treatment of patients with viral hepatitis and its influence on liver function indicators.Method:A total of 100 patients with viral hepatitis admitted to Yingtan City People's Hospital from January 2018 to June 2022 were selected,they were divided into comparison group and combination group according to simple randomization method,with 50 cases in each group.All patients were treated with symptomatic treatment,and on this basis,the comparison group was given Reduced Glutathione,the combination group was treated with Ademetionine combined with Reduced Glutathione.All patients were continuously treated for 4 weeks.The clinical effects of the two groups were compared after treatment,liver function indexes[alanine aminotransferase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST)],inflammation indexes[C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and oxidative stress indexes[malondialdehyde(MDA),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)]were compared between the two groups before and after treatment.Result:After treatment,the clinical effect of combination group was better than that of comparison group,and the total effective rate was higher than that of comparison group(P<0.05).The levels of ALT,TBIL,AST,CRP,IL-6,TNF-αand MDA in the two groups after treatment were reduced compared with those before treatment(P<0.05),and the levels in combination group were lower than those in comparison group(P<0.05).The levels of GSH-Px and SOD after treatment in the two groups were enhanced compared to before treatment(P<0.05),and the levels in combination group were higher than those in comparison group(P<0.05).Conclusion:Ademetionine combined with Reduced Glutathione in the treatment of viral hepatitis can significantly enhance the clinical efficacy,improve the liver function,relieve the inflammatory response and oxidative stress response.

关 键 词：腺苷蛋氨酸 还原型谷胱甘肽 病毒性肝炎 肝功能 

分 类 号：R512.6[医药卫生—内科学]