巨噬细胞极化与动脉粥样硬化斑块稳定性的研究进展  

Research progress on macrophage polarization and atherosclerotic plaque stability

作　　者：刘理 谢燕飞(指导)[1] 余军 LIU Li;XIE Yanfei;YU Jun(Center Office of Translational Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学医学转化中心,南昌330004

出　　处：《中国免疫学杂志》2023年第10期2115-2121,共7页Chinese Journal of Immunology

基　　金：江西省自然科学基金面上项目(20212BAB206008);江西省重点实验室项目(20202BCD42014);江西省教育厅科技计划项目(GJJ190650)。

摘　　要：动脉粥样硬化是一种慢性炎症性疾病,其中粥样斑块的形成与演变直接影响疾病进程。斑块中纤维帽变薄、脂核区增大、胶原降解酶增多等都会影响斑块稳定性,导致斑块破裂,并进一步形成血栓,最终引发一系列心血管疾病。巨噬细胞泡沫化后构成粥样斑块中的重要成分。近年研究发现巨噬细胞不同表型占比影响斑块稳定性。本文就巨噬细胞表型、巨噬细胞极化对斑块稳定性的影响及相关机制进行综述。Atherosclerosis is a chronic inflammatory disease in which formation and evolution of atherosclerotic plaques directly affect progression of disease.There are many factors that affect stability of plaques such as thinning of fibrous cap,enlargement of lipid nucleus and increase of collagenase,which can lead to plaque rupture and formation of thrombus and ultimately lead to a series of cardiovascular diseases.Macrophage foam constitutes an important component in atheromatous plaques.In recent years,studies have found that proportions of macrophages with different phenotypes affect stability of plaque.This article reviews relationship between macrophage phenotypes,polarization and plaque stability and related mechanisms.

关 键 词：巨噬细胞 极化 斑块稳定性 

分 类 号：R392.12[医药卫生—免疫学]