DCE-MRI和DSC-MRI参数对非增强T_(2)高信号病变胶质母细胞瘤患者早期进展的评估价值  

The Value of DCE-MRI and DSC-MRI Parameters in Evaluating the Early Progression of Glioblastoma Patients with Non Enhanced T_(2) High Signal Lesions

作　　者：唐丹丹 胡玮 李雪 TANG Dan-dan;HU Wei;LI Xue(Department of Radiology,Lingling Hospital,Yongzhou Central Hospital,Yongzhou 425000,Hunan Province,China)

机构地区：[1]永州市中心医院零陵院区放射科,湖南永州425000

出　　处：《中国CT和MRI杂志》2023年第10期17-19,共3页Chinese Journal of CT and MRI

基　　金：湖南省卫生健康委科研立项课题(20201412)。

摘　　要：目的探讨动态增强磁共振成像(DCE-MRI)和动态磁敏感增强灌注成像(DSC-MRI)参数对非增强T2高信号病变胶质母细胞瘤(GBM)患者早期进展的评估价值。方法回顾性分析2018年01月-2021年12月本院收治的76例GBM患者临床资料,术前均行DCE-MRI、DSC-MRI检查并接受标准化治疗。术后第6个月根据神经肿瘤学反应评估标准将患者分为早期进展组(37例)与非早期进展组(39例),比较两组间术前非增强T2高信号病变的DCE-MRI、DSCMRI参数差异。通过绘制受试者工作特征(ROC)曲线并计算曲线下面积(AUC)分析DCE-MRI、DSC-MRI参数对非增强T2高信号病变GB M患者早期进展的评估价值。采用多因素Cox比例风险回归分析具有评估价值指标是否为其独立预后因素。结果早期进展组的K^(trans)、Kep、Ve以及rCBV显著高于非早期进展组(P<0.05),通过绘制ROC曲线并计算AUC发现,Ktrans、Kep、Ve以及rCBV均对非增强T2高信号病变GBM患者早期进展有一定的评估价值,将以上具有评估价值指标采用多因素Cox比例风险回归分析发现,K^(trans)、Kep、Ve以及rCBV均是非增强T2高信号病变GBM患者的独立预后因素(P<0.05)。结论DCE-MRI参数(K^(trans)、Kep、Ve)、DSC-MRI参数(rCBV)是非增强T2高信号病变GBM患者的独立预后因素,对其早期发展具有一定的评估价值。Objective To investigate the value of dynamic enhanced magnetic resonance imaging(DCE-MRI)and dynamic magnetic sensitivity enhanced perfusion imaging(DSC-MRI)parameters in evaluating the early progression of glioblastoma(GBM)patients with non enhanced T_(2) high signal lesions.Methods Retrospective analysis was made on the clinical data of 76 GBM patients admitted to our hospital from January 2018 to December 2021.All patients underwent DCE-MRI and DSC-MRI before operation and received standardized treatment.At the 6th month after operation,the patients were divided into early progression group(37 cases)and non early progression group(39 cases)according to the evaluation criteria of neurooncology response.The differences of DCE-MRI and DSC-MRI parameters of non enhanced T_(2) hyperintense lesions before operation were compared between the two groups.By drawing the ROC curve and calculating the area under the curve(AUC),the evaluation value of DCE-MRI and DSC-MRI parameters on the early progress of GBM patients with non enhanced T_(2) hyperintense lesions was analyzed.Multivariate Cox proportional hazard regression analysis was used to evaluate whether the valuable indicator was an independent prognostic factor.Results The K^(Trans),K_(ep),V_(e) and rCBV of non enhanced T2 hyperintense lesions in the early stage progression group were significantly higher than those in the non early stage progression group(P<0.05).By drawing ROC curve and calculating AUC,it was found that K^(Trans),K_(ep),V_(e) and rCBV all had a certain evaluation value for the early stage progression of GBM patients with non enhanced T2 hyperintense lesions.Using multivariate Cox proportional risk regression analysis of the above indicators with evaluation value,it was found that K^(Trans),K_(ep),V_(e) and rCBV were independent prognostic factors in GBM patients with non enhanced T_(2) hyperintense lesions(P<0.05).Conclusion DCE-MRI parameters(K^(Trans),K_(ep),V_(e))and DSC-MRI parameters(rCBV)are independent prognostic factors of GBM patients w

关 键 词：胶质母细胞瘤 DCE-MRI DSC-MRI 非增强T_(2)高信号 早期进展 评估价值 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]