磁共振DTI及DTT技术在成人视放射病变中的初步临床应用  

Preliminary Clinical Application of Magnetic Resonance DTI and DTT Techniques in Adult Visual Radiation Lesions

作　　者：吴永顺[1] 黄穗乔[2] 刘盼丽 元建鹏[3] WU Yong-shun;HUANG Sui-qiao;LIU Pan-li;YUAN Jian-peng(Department of Radiology,Guangzhou First People’s Hospital,Guangzhou 511457,Guangdong Province,China;Department of Radiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China;Department of Radiology,The Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 518107,Guangdong Province,China)

机构地区：[1]广州市第一人民医院放射科,广东广州511457 [2]中山大学附属孙逸仙纪念医院放射科,广东广州510120 [3]中山大学附属第七医院放射科,广东深圳518107

出　　处：《中国CT和MRI杂志》2023年第10期27-29,共3页Chinese Journal of CT and MRI

摘　　要：目的应用磁共振弥散张量成像(DTI)及弥散张量纤维束成像(DTT)技术评估成人视放射病变的各向异性程度、视放射神经纤维束构象特征及临床价值及探讨视放射病变对外侧膝状体(LGN)形态学的影响。方法收集经磁共振检查、临床资料或手术病理证实累及视放射的脑内病变12例及磁共振检查无异常的健康体检者12例,以上受检者均进行过磁共振DTI及DUALTSE序列扫描。根据是视放射是否受累及,将12对视放射分成病变组、对照组,通过后处理软件分别获得部分各项异性指数(FA)值、表观弥散系数(ADC)值、平均纤维束长度(ML)、单位像素纤维束数目(MF)、LGN的高度与体积及进行纤维束追踪与成像分析,且两两比较进行统计学分析。结果12例病例中有16个视放射纤维束表现为不同程度的纤维束稀疏、移位或破坏,累及视放射的病变可导致LGN大小、形态甚至信号发生一定改变,且病例组与健康组比较具有统计学差异性,其ADC值、ML值及MF值均较健康组有所升高,但差异无统计学意义,病变组与对照组间各指标比较均无统计学意义。累及视放射的病变可导致LGN形态或信号发生一定改变,病例组LGN高度及体积的缩小与健康组比较具有统计学差异性。结论DTI及DTT技术可作为评价颞、枕部病变所致视放射及LGN形态、功能改变的既安全又客观指标;术前运用DTT技术对保护具有重要功能的白质纤维束及了解病变与该纤维束之间的关系具有重要临床意义。Objective Diffusion tensor imaging(DTI)and diffusion tensor tractography(DTT)were used to evaluate the degree of anisotropy,conformational characteristics,and clinical value of optic radiation nerve fiber bundles in adults,and to explore the effect of optic radiation lesions on the morphology of lateral geniculate body(LGN).Methods 12 cases of brain lesions involving visual radiation and 12 cases of normal physical examination were collected,which were confirmed by magnetic resonance examination,clinical data or operation,and pathology,and all of the above subjects were scanned by DTI and DUAL_TSE sequence.According to whether visual radiation was involved,12 pairs of visual radiation were divided into a lesion group and a control group.Partial anisotropy index(FA),apparent diffusion coefficient(ADC),average fiber bundle length(ML),number of fiber bundles per pixel(MF),height,and volume of LGN were obtained by post-processing software.Results Among the 12 cases,16 optic radiation fiber bundles showed thinning,displacement or destruction in varying degrees,and the lesions involving visual radiation could lead to certain changes in the size,shape and even signal of LGN,and there was a statistical difference between the case group and the healthy group.The values of ADC,ML and MF were higher than those in the normal group,but there was no significant difference between the disease group and the control group.The pathological changes involving visual radiation can lead to certain changes in the shape or signal of LGN.The reduction of LGN height and volume in the case group is statistically different from that in the healthy group.Conclusion DTI and DTT techniques can be used as safe and objective indexes to evaluate the morphological and functional changes of visual radiation and LGN caused by temporal and occipital lesions,and the use of the DTT technique before operation is of clinical significance to protect the white matter fiber bundle with important function and to understand the relationship between the lesion

关 键 词：磁共振成像 扩散张量成像 脑白质纤维束示踪 视放射 外侧膝状体 

分 类 号：R445.2[医药卫生—影像医学与核医学]