中药治疗腹泻型肠易激综合征的生物靶标研究进展  

Research progress on biological targets of traditional Chinese medicine in the treatment of diarrhea-type irritable bowel syndrome

作　　者：吴心悦 丁可欣 吴飞[1] 林晓[1] WU Xin-yue;DING Ke-xin;WU Fei;LIN Xiao(Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203

出　　处：《天然产物研究与开发》2023年第10期1820-1831,共12页Natural Product Research and Development

基　　金：上海市卫生健康委员会科研基金(201940296)。

摘　　要：腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)是肠易激综合征(irritable bowel syndrome,IBS)最常见的亚型。IBS-D的主要病因包括胃肠道炎症反应、内脏敏感性增加、脑-肠轴异常、肠道微生态紊乱、肠道屏障受损等。在这些病理进程中存在引发IBS-D的关键因子,因此可以寻找IBS-D发病的关键信号通路及关键信号因子,作为治疗IBS-D的生物靶标,通过抑制或调节这些生物靶标,以达到防治IBS-D的目的。研究显示,以中医药途径干预治疗IBS-D是一种安全且有效的方法,无论是单味中药或是中药复方,均显示对IBS-D的发病机制中的多种关键通路及关键信号因子具有调节作用。本文就中药对治疗IBS-D发病进程中的关键生物靶标的研究进展进行综述,为IBS-D治疗药物作用机制探索及新药开发提供思路。Diarrhea-predominant irritable bowel syndrome(IBS-D)is the most common subtype of irritable bowel syndrome(IBS).The main causes of IBS-D include gastrointestinal inflammation,increased visceral sensitivity,abnormal brain-gut axis,intestinal microecological disorder,and intestinal barrier damage.There are key factors that trigger IBS-D in these pathological processes.Therefore,the key signaling pathways and key signaling factors of the pathogenesis of IBS-D can be sought as biological targets for the treatment of IBS-D,and the purpose of preventing and treating IBS-D can be achieved by inhibiting or regulating these biological targets.Studies have shown that traditional Chinese medicine(TCM)is a safe and effective way to intervene in the treatment of IBS-D.Both single TCM and TCM compound have been shown to have regulatory effects on multiple key pathways and key signaling factors in the pathogenesis of IBS-D.This article reviews the research progress of biological targets related to traditional Chinese medicine in the treatment of the pathogenesis of IBS-D,so as to provide ideas for the exploration of the mechanism of action of drugs for IBS-D and the development of new drugs.

关 键 词：中药 腹泻型肠易激综合征 生物靶标 胃肠道炎症 内脏敏感性 

分 类 号：R285.5[医药卫生—中药学]