热休克蛋白90在HBV复制中的作用  

Role of heat shock protein 90 in hepatitis B virus replication

作　　者：花胤 方海丽[3] 刘守胜 辛永宁[1] 张梅[1] 宣世英[1] HUA Yin;FANG Haili;LIU Shousheng;XIN Yongning;ZHANG Mei;XUAN Shiying(Department of Infectious Diseases,Qingdao Municipal Hospital,Qingdao,Shandong 266011,China;Clinical Research Center,Qingdao Clinical Medical College Affiliated to Nanjing Medical University,Qingdao Municipal Hospital,Qingdao,Shandong 266011,China;Department of Infectious Diseases,Qingdao Eighth People’s Hospital,Qingdao,Shandong 266000,China)

机构地区：[1]南京医科大学附属青岛临床医学院,青岛市市立医院感染性疾病科,山东青岛266011 [2]南京医科大学附属青岛临床医学院,青岛市市立医院临床研究中心,山东青岛266011 [3]青岛市第八人民医院感染性疾病科,山东青岛266000

出　　处：《临床肝胆病杂志》2023年第10期2443-2447,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(32171277)。

摘　　要：HBV传播范围广,慢性感染状态多,治愈率低,提高HBV治愈率有助于改善患者的长期预后状况。热休克蛋白90(Hsp90)是广泛存在于生物体内的一种分子伴侣蛋白。近年来越来越多的研究表明,Hsp90与HBV感染有关,在HBV的复制过程中起重要作用,可与病毒的特定蛋白相互作用促进病毒复制,也可与宿主自身蛋白相互作用来发挥功能。本文就近年来Hsp90在HBV复制中的作用相关研究进展作一综述,以期为以Hsp90为靶点的抗HBV药物研发与HBV防治提供新的理论指导和方向。Hepatitis B virus(HBV)has the characteristics of wide transmission,a high chronic infection rate,and a low cure rate,and improving the cure rate of HBV may help to improve the long-term prognosis of patients.Heat shock protein 90(Hsp90)is a chaperone protein widely present in organisms.In recent years,more and more studies have shown that Hsp90 is associated with HBV infection and plays an important role in HBV replication.It can not only interact with specific proteins of the virus to promote its replication,but also interact with the host’s own proteins to perform its function.This article reviews the role of Hsp90 in HBV replication in recent studies,so as to provide new theoretical guidance and directions for the development of new anti-HBV drugs targeting Hsp90 and the prevention and treatment of HBV infection in the future.

关 键 词：乙型肝炎病毒 HSP90热休克蛋白质类 病毒复制 

分 类 号：R373.21[医药卫生—病原生物学]