妊娠合并戊型肝炎研究进展  

Research advances in hepatitis E virus infection in pregnancy

作　　者：钟曼华 王静月 黄缘[2] ZHONG Manhua;WANG Jingyue;HUANG Yuan(Department of Infectious Diseases and Hepatology,Zhuhai People’s Hospital&Zhuhai Hospital Affiliated to Jinan University,Zhuhai,Guangdong 519000,China;Department of Hepatology,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)

机构地区：[1]珠海市人民医院(暨南大学附属珠海医院)感染肝病科,广东珠海519000 [2]清华大学附属北京清华长庚医院肝胆内科,清华大学临床医学院,北京102218

出　　处：《临床肝胆病杂志》2023年第10期2448-2453,共6页Journal of Clinical Hepatology

摘　　要：既往研究显示妊娠合并戊型肝炎病毒(HEV)感染易发展为肝衰竭,还可能伴有流产、死胎和垂直传播等不良结局,尤其是在HEV基因1型和2型流行的国家。我国近年已转为以HEV基因4型为主的散发流行,虽然研究显示我国大多数HEV感染的孕妇没有明显的临床症状,但观察到很高的妊娠不良结局发生率。本综述回顾了近年关于妊娠合并戊型肝炎的相关研究,包括病原学及流行病学、预后、重症化相关机制,以及治疗及预后相关进展,最后对妊娠合并戊型肝炎的筛查及预后评估提出了建议。Previous studies have shown that hepatitis E virus(HEV)infection in pregnancy can cause liver failure and adverse pregnancy outcomes such as miscarriage,stillbirth,and vertical transmission,especially in countries where HEV genotypes 1 and 2 are prevalent.In recent years,HEV infection in China is sporadic and is mainly caused by HEV genotype 4,and although studies have shown that most pregnant women with HEV infection in China have no signfinicant clinical symptoms,there is still a high incidence rate of adverse pregnancy outcomes.This article reviews the recent studies on HEV infection in pregnancy,including the advances in pathogenesis,epidemiology,prognosis,mechanism of severe exacerbation,treatment,and prognosis,and puts forward recommendations for the screening and evaluation of HEV infection in pregnancy.

关 键 词：戊型肝炎病毒 孕妇 妊娠并发症 肝功能衰竭 

分 类 号：R714.251[医药卫生—妇产科学]