Self-reporting fluorescence deciphers the antibacterial nature of cationic amphiphiles:Monomer or aggregate?  

作　　者：Chengcheng Zhou Zeyu Ding Weijiang Guan Ben Zhong Tang 

机构地区：[1]School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou,China [2]State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing,China [3]School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,China

出　　处：《Aggregate》2023年第5期214-223,共10页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:22002137;Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20200920;Beijing Natural Science Foundation,Grant/Award Number:2212013;Shenzhen Key Laboratory of Functional Aggregate Materials,Grant/Award Number:ZDSYS20211021111400001。

摘　　要：Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process.Herein,three bola-type cationic amphiphiles with aggregation-induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate.The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton.The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria.The aggregates with cationic charges first attach to bacterial surface,and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane.Further,our results reveal the vital role of stability of aggregates during antimicrobial process,shedding light on the rational design of high-efficient antimicrobials.

关 键 词：aggregation-induced emission antibacterial nature cationic amphiphiles self-assembly stability 

分 类 号：O63[理学—高分子化学]