整合致孔肽的纳米递药系统的研究进展  

Research Progress in Nano Drug Delivery System Integrating Pore-Forming Peptides

作　　者：申春姣 周秀婷 丛可心 赵锋[1] 张佳 何朝星[1] 曹德英[1] 杨少坤[1] 张国强[3,4] 向柏 SHEN Chun-jiao;ZHOU Xiu-ting;CONG Ke-xin;ZHAO Feng;ZHANG Jia;HE Chao-xing;CAO De-ying;YANG Shao-kun;ZHANG Guo-qiang;XIANG Bai(School of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China;The Fourth Hospital of Shijiazhuang,Shijiazhuang 050035,China;Department of Dermatology,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Construction Unit of the Sub-center of the National Center for Clinical Medical Research on Skin and Immunological Diseases,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学药学院,石家庄050017 [2]石家庄市第四医院药剂科,石家庄050035 [3]河北医科大学第一医院皮肤科,石家庄050031 [4]国家皮肤与免疫疾病临床医学研究中心分中心建设单位,石家庄050000

出　　处：《中国药学杂志》2023年第12期1057-1064,共8页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81973251);河北省2021年度医学科学研究课题资助(20211108)。

摘　　要：纳米载体普遍具有安全、高效及靶向性等优点,是一种极具潜力的药物递送载体。致孔肽是一种线性阳离子膜致孔多肽,具有多种生物用途。致孔肽既是一类细胞递送促进剂,也是一种新型的肿瘤杀伤多肽(克服耐药性)。在结合致孔肽构建的纳米递送系统中,有些致孔肽可促进药物内涵体逃逸进而提高胞质递送效率,有些具有肿瘤靶向或内质网靶向作用,有些则作为抗癌药物发挥癌症治疗作用。笔者对结合致孔肽构建的纳米递送系统的研究进行了整理和归纳,对应用到的致孔肽种类进行了总结,并对致孔肽在纳米递送系统中发挥的作用进行了梳理和分类,以期为构建更合理、更有效的整合致孔肽的纳米药物递送平台提供参考。Nanocarriers generally have the advantages of safety,high efficiency and targeting,and are a class of potential drug delivery vehicles.As a kind of linear cationic membrane pore-forming polypeptides with a variety of biological uses,pore-forming peptides(PFPs)can be used not only as a class of cell delivery enhancer,but also as a new type of tumor-killing polypeptides(overcoming drug resistance).In the nano-delivery system constructed by combining pore-forming peptides,some pore-forming peptides can promote endosomal escape of drug and thus improve the efficiency of cytoplasmic delivery,some have tumor cell targeting or endoplasmic reticulum targeting effects,and some act as anticancer drugs.This review sums up the studies on nano-delivery systems combined with pore-forming peptides,summarizes the types of pore-forming peptides that have been applied in nano-delivery systems,and classifies the role of pore-forming peptides in nano-delivery systems,thereby providing a reference for the construction of a more reasonable and effective nano drug delivery platform integrating pore-forming peptides.

关 键 词：致孔肽 纳米药物递送系统 内涵体逃逸 胞质递送 肿瘤靶向 

分 类 号：R944[医药卫生—药剂学]