Caco-2单细胞模型及共培养模型的应用进展  

Progress in Application of Caco-2 Single Cell Model and Co-culture Model

作　　者：孟云 徐宇航 吴龙 储晓琴 MENG Yun;XU Yu-hang;WU Long;CHU Xiao-qin(School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Hefei 230012,China;Engineering Technology Research Center of Modern Pharmaceutical Preparation,Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,合肥230012 [2]药物制剂技术与应用安徽省重点实验室,合肥230012 [3]现代药物制剂安徽省工程技术研究中心,合肥230012

出　　处：《中国药学杂志》2023年第14期1271-1275,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81803831);安徽省科技重大专项资助(201903a07020007)。

摘　　要：近年来,人结肠腺癌细胞(Caco-2)模型常被用来预测药物或生物活性物质的人体小肠吸收及转运机制,但因其不能准确模拟肠道环境导致其应用受到一定限制。随着细胞生物学和分子生物学的发展,将Caco-2细胞与其他细胞进行共培养,这在一定程度上解决了Caco-2细胞模型的局限性。笔者对Caco-2细胞模型以及与其他细胞的共培养模型在药物以及食品研究中的最新应用进展进行综述。In recent years,the Caco-2 cell model has been used to predict human intestinal absorption of drugs or bioactive substances and study the mechanisms of drug transport.However,its application is limited due to its inability to accurately simulate the intestinal environment.With the development of cell biology and molecular biology,the co-culture of Caco-2 cells with other cells solves the limitations brought by a single Caco-2 cell model to a certain extent.This paper reviews the latest progress in application of Caco-2 cell model and some co-culture models with other cells in drug and food research.

关 键 词：CACO-2细胞 药物吸收 共培养模型 体外细胞模型 

分 类 号：R965.1[医药卫生—药理学]