纤维支气管镜肺泡灌洗联合乙酰半胱氨酸治疗对重症肺炎临床疗效、肺换气功能指标及细胞因子的影响  

Effects of Fiberoptic Bronchoscopic Alveolar Lavage Combined with Acetylcysteine Treatment on Clinical Efficacy,Pulmonary Ventilation Function Indexes and Cytokines in Severe Pneumonia

作　　者：陈艳乐 张石丰 楚玉洁 CHEN Yan-le;ZHANG Shi-feng;CHU Yu-jie(Department of Respiratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属郑州中心医院呼吸内科,郑州450000

出　　处：《四川解剖学杂志》2023年第3期13-15,35,共4页Sichuan Journal of Anatomy

摘　　要：目的:探讨纤维支气管镜肺泡灌洗联合乙酰半胱氨酸治疗对重症肺炎临床疗效、肺换气功能指标及细胞因子的影响.方法:选取2019年6月至2022年10月本院收治的92例重症肺炎患者作为研究对象,按照治疗方案不同分为观察组(n=50,纤维支气管镜肺泡灌洗联合乙酰半胱氨酸治疗)和对照组(n=42,纤维支气管镜肺泡灌洗联合常规药物治疗),对比两组治疗效果.结果:观察组治疗后总有效率94.00%(47/50)高于对照组71.43%(30/42),差异有统计学意义(P<0.05).两组治疗后血氧饱和度(SaO_(2))、血氧分压(PaO_(2))以及计算氧合指数(O1)各项指标均较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05).两组治疗后细胞间黏附分子1(ICAM-1)以及肾上腺髓质素(ADM)水平均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05).两组均无明显不良反应.结论:纤维支气管镜肺泡灌洗联合乙酰半胱氨酸更有利于改善重症肺炎患者临床疗效,且具有一定安全性.Objective:To investigate the effects of fiberoptic bronchoscopic alveolar lavage combined with acetylcysteine on the clinical efficacy,pulmonary ventilation function indicators and cytokines in severe pneumonia.Methods:Atotal of 92 patients with severe pneumonia admitted to our hospital from June 2019 to October 2022 were selected and divided into the observation group(n=50,bronchoscopic alveolar lavage combined with acetylcysteine treatment)and the control group(n=42,bronchoscopic alveolar lavage combined with conventional drug treatment).Compare the treatment efects between the two groups.Results:After treatment,the total effective rate in the observation group(94.00%,47/50)was higher than that in the control group(71.43%,30/42)(P<0.05).After treatment,the indicators of SaO_(2),PaO_(2) and oxygenation index(OI)in the two groups were all increased compared with before treatment,and the observation group was higher than the control group(P<0.05).After treatment,the levels of intercellular cell adhesion molecule-1(ICAM-1)and adrenomedulin(ADM)in the two groups were decreased compared with before treatment,and the observation group was lower than the control group(P<0.05).After observation and statistics,there were no obvious adverse reactions in the two groups.Conclusion:Fibrobronchoscopic alveolar lavage combined with acetylcysteine is more conducive to improving the clinical efficacy of patients with severe pneumonia,and has a certain degree of safety.

关 键 词：纤维支气管镜肺泡灌洗 乙酰半胱氨酸 重症肺炎 临床疗效 换气功能指标 细胞因子 

分 类 号：R563.1[医药卫生—呼吸系统]