糖皮质激素联合沙丁胺醇雾化吸入对急性加重期慢性阻塞性肺疾病患者通气功能及炎症因子的影响  

Effects of Glucocorticoid Combined with Salbutamol Aerosol Inhalation on Ventilation Function and Inflammatory Factors in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease

作　　者：玉彦坤 YU Yan-kun(Department of Respiratory,Hua County Central Hospital,Anyang 456400,China)

机构地区：[1]滑县中心医院呼吸内科,安阳456400

出　　处：《四川解剖学杂志》2023年第3期32-35,共4页Sichuan Journal of Anatomy

摘　　要：目的:分析急性加重期慢性阻塞性肺疾病(简称慢阻肺)患者联用糖皮质激素与沙丁胺醇治疗的效果.方法:选取2022年1月至2022年12月期间本院收治的急性加重期慢阻肺患者80例作为研究对象,采用抽签法分为研究组和对照组,各40例.在常规治疗基础上,研究组雾化吸入加沙丁胺醇的糖皮质激素治疗,对照组仅雾化吸入糖皮质激素治疗,对比两组效果.结果:与对照组比较,研究组治疗后总有效率和比气道传导率(sGAW)更高,比气道阻力(sRAW)、气道阻力(RAW)更低,差异有统计学意义(P<0.05),且研究组治疗后各炎性因子指标水平均低于对照组,血气分析改善情况优于对照组,差异有统计学意义(P<0.05).两组间不良反应比较,差异无统计学意义(P>0.05).结论:糖皮质激素与沙丁胺醇联用的临床疗效确切,可有效调节机体炎性因子水平,改善患者通气和血气状况,且安全性高.Objective:analyze the effect of glucocorticoid combined with Salbutamol on chronic obstructive pulmonary disease(COPD)in acute exacerbation.Methods:Eighty patients with acute exacerbation of COPD admitted to our hospital from January 2022 to December 2022 were selected and divided into two groups using a lottery method,with 40 patients in each group.In addition to routine treatment,the study group was treated with Salbutamol,and the control group was treated with aerosol inhalation of glucocorticoid.The effects of the two groups were compared.Results:Compared with the control group,the study group had higher total effective rate and specific airway conductance(sGAW)affer treatment,lower airway resistance(sRAW)and airway resistance(RAW)(P<0.05),and the levels of inflammatory factors in the study group were lower than those in the control group after treatment.The improvement of blood gas analysis was better than that in the control group(P<0.05).There was no statistically significant difference in the adverse reactions between the two groups(P>0.05).Conclusion:The combination of glucocorticoid and Salbutamol has a definite clinical effect,can effectively regulate the level of inflammatory factors,improve the ventilation and blood gas status of patients,and has high safety.

关 键 词：急性加重期 糖皮质激素 通气功能 慢阻肺 沙丁胺醇 

分 类 号：R563.9[医药卫生—呼吸系统]