HIV感染者急性期血浆CXCL13水平与疾病进展的关系  

The relationship between plasma CXCL13 level during primary infection and disease progression in HIV infected individuals

作　　者：王悦[1,2,3] 尹晓婉 王卓 张子宁[1,2,3] 傅雅静 丁海波[1,2,3] 韩晓旭 姜拥军[1,2,3] WANG Yue;YIN Xiaowan;WANG Zhuo;ZHANG Zining;FU Yajing;DING Haibo;HAN Xiaoxu;JIANG Yongjun(NHC Key Laboratory of AIDS Immunology(China Medical University),National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,Shenyang 110001,Liaoning,China;Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001 Liaoning,China;Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,Liaoning,China)

机构地区：[1]国家卫生健康委员会艾滋病免疫学重点实验室(中国医科大学)国家医学检验临床医学研究中心中国医科大学附属第一医院,沈阳110001 [2]中国医学科学院艾滋病免疫学重点实验室,沈阳110001 [3]辽宁省艾滋病免疫学重点实验室,沈阳110001

出　　处：《中国艾滋病性病》2023年第8期854-859,共6页Chinese Journal of Aids & STD

基　　金：国家重点研发计划(2021YFC2301802);国家“十三五”科技重大专项(2017ZX10201101)。

摘　　要：目的探究HIV感染者急性期血浆CXCL13水平与病毒载量及CD4细胞数量间的关系,评估其预测疾病进展及ART后免疫重建的能力。方法选取中国医科大学附属第一医院急性期HIV感染者54例,对标本CXCL13水平、病毒载量和CD4细胞数量进行检测。结果以set-point高低分组,set-point高组(lgVL≥3.5拷贝/mL)CXCL13水平明显高于set-point低组(lgVL<3.5拷贝/mL,P=0.0135),以感染一年的CD4细胞数量高低分组,CD4细胞高组(≥500个/μL)CXCL13水平明显低于CD4细胞低组(<500个/μL,P=0.0057),以ART一年的CD4细胞数量高低分组,CD4细胞高组(≥500个/μL)CXCL13水平明显低于CD4细胞低组(<500个/μL,P=0.0257),Kaplan-Meier生存分析显示急性期血浆CXCL13水平高的HIV感染者,其疾病进展更快,ART后免疫恢复更差(P=0.0351;P=0.0005)。结论急性期血浆CXCL13水平可以预测HIV感染的疾病进展及ART后的免疫恢复。Objective To explore the relationship between plasma CXCL13 level during primary infection and HIV viral parameters such as viral loads and CD4+T cell counts,to evaluate its ability to predict disease progression and immune restoration after antiviral therapy(ART).Methods A total of 54 HIV-infected individuals were selected from The First Affiliated Hospital of China Medical University.The plasma CXCL13 level,the viral loads,and the CD4+T cell counts were tested.Results Plasma CXCL13 level in the high set-point group(lgVL≥3.5 copies/mL)was higher than that in the low set-point group(lgVL<3.5 copies/mL,P=0.0135).It was also significantly lower in the high CD4+T cell group(CD4+T≥500 cells/μL within one year after HIV infection)than that in the low CD4+T cell group(CD4+T<500 cells/μL within one year after HIV infection,P=0.0057).Plasma CXCL13 level was significantly lower in people with CD4+T≥500 cells/μL within one year after ART,compared with those with CD4+T<500 cells/μL within one year after ART(P=0.0257).Kaplan-Meier survival analysis showed that HIV-infected individuals with high CXCL13 levels during primary infection had faster disease progression and poorer immune restoration after ART(P=0.0351;P=0.0005).Conclusions The CXCL13 level during primary infection can predict HIV disease progression and immune restoration after ART.

关 键 词：CXCL13 艾滋病病毒 疾病进展 免疫恢复 

分 类 号：R373.9[医药卫生—病原生物学] R512.91[医药卫生—基础医学]