HIV/AIDS患者衰弱发生率及影响因素的Meta分析  

Incidence and influencing factors of frailty in HIV/AIDS patients:a meta-analysis

作　　者：吕开月 廖喜琳[2] 熊文琴 付晶晶 程树锦 姜枫[1] LYU Kaiyue;LIAO Xilin;XIONG Wenqin;FU Jingjing;CHENG Shujin;JIANG Feng(Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,Guangxi,China;Guangxi University of Traditional Chinese Medicine Affiliated School of Traditional Chinese Medicine,Nanning 530022,Guangxi,China;The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China)

机构地区：[1]广西中医药大学附属瑞康医院,南宁530011 [2]广西中医药大学附设中医学校,南宁530022 [3]西南医科大学附属医院,四川泸州646000

出　　处：《中国艾滋病性病》2023年第8期948-952,F0003,共6页Chinese Journal of Aids & STD

基　　金：国家自然科学基金地区基金项目(82260901)。

摘　　要：目的系统评价HIV/AIDS患者衰弱发生率及影响因素。方法计算机检索PubMed、Web of Science、Co⁃chrane Library、Embase、Scopus、中国知网、中国生物医学文献数据库、万方、维普和读秀数据库,检索时限从建库至2023年2月24日,纳入关于HIV/AIDS患者衰弱发生率及影响因素的文献,利用RevMan5.4和Sata17.0软件进行Meta分析。结果共纳入23篇,合计26753名患者,共涉及18个影响因素。Meta分析结果显示:HIV/AIDS患者衰弱发生率为12%[95%CI(10%~15%)];CD4细胞<200个/μL(OR=2.14,95%CI:1.69~2.71)、高龄(OR=1.13,95%CI:1.09~1.18)、抑郁(OR=1.20,95%CI:1.13~1.27)、慢性阻塞性肺疾病(OR=2.31,95%CI:1.67~3.20)、神经认知障碍(OR=2.44,95%CI:1.91~3.14)、女性(OR=1.73,95%CI:1.49~2.00)、吸烟史(OR=1.60,95%CI:1.43~1.80)是HIV/AIDS患者发生衰弱的危险因素。结论HIV/AIDS患者衰弱发生率较高,临床工作者除关注患者本身外,还应针对以上高危人群进行早期筛查与干预,避免衰弱的发生。Objective To explore the incidence and influencing factors of frailty among people living with HIV(PLWH).Methods We retrieved English and Chinese databases including PubMed,Web of Science,Cochrane Library,Embase,Scopus,CNKI,CBM,Wanfang,VIP,and Duxiu to search literature published from the inception to February 24,2023,related to incidence and influencing factors of frailty among PLWH.A meta-analysis was conducted by revMan5.4 and sata17.0 software.Results A total of 23 literatures were included with 26,753 subjects and 18 influencing factors.Meta-analysis results showed that the incidence of frailty among PLWH was 12.%[95%CI(10%-15%)].Seven statistically significant influence factors,including having CD4+cell<200/μL(OR=2.14,95%CI:1.69-2.71),with advanced age(OR=1.13,95%CI:1.09-1.18),having depression(OR=1.20,95%CI:1.13-1.27),with COPD(OR=2.31,95%CI:1.67-3.20),with neurocognitive impairment(OR=2.44,95%CI:1.91-3.14),being female(OR=1.73,95%CI:1.49-2.00),and with a smoking history(OR=1.60,95%CI:1.43-1.80)were reported to be related to frailty among PLWH.Conclusions The meta-analysis suggested a high frailty incidence among PLWH.Health providers should pay attention to early screening of frailty and provide tailored interventions according to the psychological state to prevent the occurrence of frailty among PLWH.

关 键 词：艾滋病 衰弱 发生率 影响因素 META分析 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]