血小板计数联合凝血四项检查在肾病综合征诊断中的应用价值  

Application Value of Platelet Count and Four-Item Coagulation Test in Diagnosis of Nephrotic Syndrome

作　　者：王亚 梅玉峰 熊钻 刘庆 Wang Ya;Mei Yufeng;Xiong Zuan;Liu Qing(Clinical Laboratory Department,Ezhou Egang Hospital,Ezhou 436000,Hubei Province,China)

机构地区：[1]鄂州市鄂钢医院检验科,湖北鄂州436000

出　　处：《中国社区医师》2023年第28期80-82,共3页Chinese Community Doctors

摘　　要：目的:分析血小板计数联合凝血四项检查在肾病综合征诊断中的应用价值。方法:选取2021年5月—2022年5月鄂州市鄂钢医院收治的50例肾病综合征失代偿期患者作为观察A组,选取50例肾病综合征代偿期患者作为观察B组,选取50例健康体检者作为对照组。三组均接受血小板计数与凝血四项检查。比较三组凝血四项与血小板计数水平,以肾穿刺检查结果为“金标准”,计算凝血四项与血小板计数诊断肾病综合征的准确率、特异度。结果:观察A组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)水平高于观察B组与对照组,血小板计数低于观察B组与对照组,差异有统计学意义(P<0.05);观察B组PT、APTT、TT、FIB水平高于对照组,血小板计数低于对照组,差异有统计学意义(P<0.05)。血小板计数检查、凝血四项联合检查诊断肾病综合征的准确度、特异度高于单独检查,差异有统计学意义(P<0.05)。结论:血小板计数联合凝血四项检查诊断肾病综合征的效能较高,在病情评估方面具有参考价值。Objective:To analyze the application value of platelet count and four-item coagulation test in the diagnosis of nephrotic syndrome.Methods:A total of 50 patients with decompensated nephrotic syndrome admitted to Ezhou Egang Hospital from May 2021 to May 2022 were selected as the observation group A,50 patients with compensated nephrotic syndrome were selected as the observation group B,and 50 healthy people participating in health examination were selected as the control group.All the subjects received platelet count and four-item coagulation test.The four-item coagulation test and platelet count levels were compared among the three groups,and the results of renal puncture examination were used as the"gold standard"to calculate the accuracy and specificity of four-item coagulation test and platelet count in the diagnosis of nephrotic syndrome.Results:The levels of prothrombin time(PT),activated partial prothrombin time(APTT),thrombin time(TT)and fibrinogen(FIB)in observation group A were higher than those in observation group B and control group,and platelet count in observation group A was lower than that in observation group B and control group,and the difference was statistically significant(P<0.05).The levels of PT,APTT,TT and FIB in observation group B were higher than those in the control group,and the platelet count in observation group B was lower than that in the control group,and the difference was statistically significant(P<0.05).The accuracy and specificity of platelet count and four-item coagulation test in the diagnosis of nephrotic syndrome were higher than those of individual test,and the difference was statistically significant(P<0.05).Conclusion:Platelet count combined with four-item coagulation test has a high efficacy in diagnosing nephrotic syndrome,and has reference value in disease evaluation.

关 键 词：血小板计数 凝血四项 肾病综合征 诊断 

分 类 号：R692[医药卫生—泌尿科学] R446.1[医药卫生—外科学]