进化视角下的人类衰老与长寿科学  

The science of human aging and longevity from an evolutionary perspective

作　　者：王钊 Wang Zhao(Protein Science Key Laboratory of the Ministry of Education,School of Pharmaceutical Sciences,Tsinghua University,Beijing 100080,China)

机构地区：[1]清华大学药学院蛋白质科学教育部重点实验室,北京100080

出　　处：《中国医学前沿杂志（电子版）》2023年第10期15-17,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金(81871095,82170873)。

摘　　要：人类的衰老是在成熟期后随增龄而发生的机体正常形态和功能的退行性改变。从进化和自然选择的角度来看,衰老并非进化的必然产物,而是一个随机事件,是在完成进化使命的繁殖期后自然选择的作用惯性,提示衰老并非生命终结的前提,因此抗衰老是可行的。抗衰老并不是抗增龄、抗死亡,而是推动健康老龄化。未来抗衰老研究和老年医学的目标应聚焦于如何减缓身体功能的衰退、减少增龄相关疾病的发生、延长健康寿命。Aging in humans,defined as the degenerative changes in physical form and function after maturity with aging during post-reproductive life,has only emerged in the last two to three centuries.From an evolutionary viewpoint,aging is not an inevitable outcome but a random event,a lingering effect of natural selection after reproductive period.Aging is not a mandatory precursor to life's end,hence making anti-aging feasible.Anti-aging does not signify opposition to aging or death,but rather promotes the concept of healthy aging.Looking ahead,the key goal of anti-aging research and geriatric medicine should be to devise strategies that slow functional decline,reduce age-related diseases,and extend healthy lifespan.

关 键 词：进化 衰老 健康老龄化 长寿 

分 类 号：R339.38[医药卫生—人体生理学]