基于肠肾轴理论探讨黄芪-丹参治疗糖尿病肾病作用机制  

To Explore the Mechanism of Astragalus Membranaceus and Salvia Miltiorrhiza in Treating Diabetic Nephropathy based on Gut-kidney Axis Theory

作　　者：李颖[1] 杨玉兰[2] LI Ying;YANG Yulan(Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)

机构地区：[1]天津中医药大学,天津300250 [2]天津中医药大学第二附属医院,天津300250

出　　处：《中医药临床杂志》2023年第10期1859-1863,共5页Clinical Journal of Traditional Chinese Medicine

摘　　要：糖尿病肾病(Diabetic Kidney Disease,DKD)患病率近年来呈不断上升趋势,威胁着人类健康。随着国内外对肠道微生态深入研究,“肠肾轴”逐渐成为研究热点,为临床治疗各种肾脏病提供理论依据。基于DKD本虚标实、气虚血瘀的病机特点,选用黄芪-丹参作为临床治疗DKD常用药对。该文从黄芪-丹参能够保护肠道屏障、调节肠道微生物代谢产物、保护肾小球滤过屏障,缓解DKD患者肠肾之间恶性循环的角度出发,进一步分析阐述其作用机制,明确其在临床中的应用价值,为其临床治疗与推广提供理论指导和科学依据。The prevalence of diabetic kidney disease(DKD)has been increasing in recent years,threatening human health.With in-depth research on intestinal microecology at home and abroad,the“Gut-Kidney Axis”has gradually become a hot research field,providing a theoretical basis for the clinical treatment of various kidney diseases.Based on the pathogenesis characteristics of DKD with deficiency in origin and excess in excess,Qi deficiency and blood stasis,Astragalus-Salvia Miltiorrhiza was selected as a common drug pair for the clinical treatment of DKD.This article starts from the perspective that Astragalus-Salvia Miltiorrhiza can protect the intestinal barrier,regulate intestinal microbial metabolites,protect the glomerular filtration barrier,and alleviate the vicious cycle between the intestine and kidney in patients with DKD.This article further analyzes and explains its mechanism of action,and clarifies its role in Its clinical application value provides theoretical guidance and scientific basis for its clinical treatment and promotion.

关 键 词：肠肾轴 糖尿病肾病 肠道菌群 黄芪丹参 

分 类 号：R259[医药卫生—中西医结合]