中药离子导入法联合氟哌噻吨美利曲辛片干预AECOPD合并焦虑抑郁状态的临床研究  

Clinical Study on the Intervention of AECOPD with Anxiety and Depression by Iontophoresis Combined with Flupentixol Melitracen Tablets

作　　者：彭磊[1] 王祺东 唐艳芬 洪玲玲 陈丽贤[1] 沙建飞 PENG Lei;WANG Qidong;TANG Yanfen;HONG Lingling;CHEN Lixian;SHA Jianfei(Qidong City Hospital of Traditional Chinese Medicine,Jiangsu Qidong 226200,China;Nantong Hospital of Traditional Chinese Medicine,Jiangsu Nantong 226001,China)

机构地区：[1]江苏省启东市中医院,江苏启东226200 [2]江苏省南通市中医院,江苏南通226001

出　　处：《中医药临床杂志》2023年第10期2018-2023,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：2021年度江苏省南通市中医医疗联盟课题(TZYK202124)。

摘　　要：目的:观察中药离子导入柴胡疏肝散对慢性阻塞性肺疾病急性加重期住院患者焦虑抑郁状态及免疫功能、凝血功能等的影响。方法:将93例符合标准的具有焦虑抑郁情绪的慢性阻塞性肺疾病急性加重期患者采用随机数字表法分为对照组(46例)和治疗组(47例),对照组采用标准西医治疗方案,治疗组在对照组的基础上加用中药离子导入疗法刺激相应穴位。比较2组治疗后疗效评价、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、慢性阻塞性肺疾病评估测试评分(CAT评分)、T淋巴细胞亚群水平、D二聚体(DDi)、纤维蛋白原(FIB)、C反应蛋白(CRP)、降钙素原(PCT)等。结果:治疗组临床症状显控率72.34%,明显高于对照组的47.83%;治疗后2组患者的SAS、SDS、CAT评分、T淋巴细胞亚群水平、DDi、FIB均优于治疗前(P<0.05),且治疗组明显优于对照组(P<0.05),但治疗后2组CRP、PCT比较,差异无统计学意义(P>0.05)。结论:西医基础治疗配合中药离子导入柴胡疏肝散临床疗效确切,能够明显降低AECOPD患者的焦虑抑郁情绪状态,同时能够改善患者的免疫及血凝状态。Objective:To observe the effect of traditional Chinese medicine iontophoresis Bupleurum Shugan Powder on anxiety,depression,immune function,and coagulation function in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease.Methods:93 patients with acute exacerbation of chronic obstructive pulmonary disease who met the criteria and had anxiety and depression were divided into a control group(46 cases)and a treatment group(47 cases)using the random number table method.The control group was treated with standard Western medicine treatment.,the treatment group added traditional Chinese medicine iontophoresis therapy to stimulate the corresponding acupoints on the basis of the control group.Compare the post-treatment efficacy evaluation,Self-rating Anxiety Scale(SAS)score,Self-rating Depression Scale(SDS)score,Chronic Obstructive Pulmonary Disease Assessment Test score(CAT score),T lymphocyte subgroup levels,D2 Polymer(DDi),fibrinogen(FIB),C-reactive protein(CRP),procalcitonin(PCT),etc.Results:The clinical symptom control rate in the treatment group was 72.34%,which was significantly higher than the 47.83%in the control group;the SAS,SDS,CAT scores,T lymphocyte subgroup levels,DDi,and FIB of the patients in the two groups after treatment were all better than before treatment(P<0.05),and the treatment group was significantly better than the control group(P<0.05),but there was no statistically significant difference in CRP and PCT between the two groups after treatment(P>0.05).Conclusion:The clinical efficacy of basic Western medicine treatment combined with traditional Chinese medicine iontophoresis Bupleurum Shugan Powder is accurate,which can significantly reduce the anxiety and depression in patients with AECOPD,and at the same time improve the patient’s immune and hemagglutination status.

关 键 词：慢性阻塞性肺疾病 焦虑 抑郁 中药离子导入法 临床疗效 

分 类 号：R244.9[医药卫生—针灸推拿学]