黄烷酮双腙类化合物的合成与结构表征  

Synthesis and Characterization of Flavanone Dihydrazone Compounds

作　　者：李春生 陈耀杨 吴利欢 LI Chun-sheng;CHEN Yao-yang;WU Li-huan(School of Chemistry and Chemical Engineering,Zhaoqing University,Guangdong Zhaoqing 526060,China)

机构地区：[1]肇庆学院环境与化学工程学院,广东肇庆526060

出　　处：《广州化工》2023年第12期66-69,共4页GuangZhou Chemical Industry

基　　金：肇庆市科技计划项目(No:2022040315022);广东省药品监督管理局科技创新项目(No:2021TDB35);广东省基础与应用基础研究基金(2020A1515111156);肇庆学院科研基金项目(QN202229);大学生创新创业训练计划项目(202310580015)。

摘　　要：不对称双腙类化合物具有显著的生物活性,在药物、农药等领域发挥着越来越重要的作用。因此,其合成方法也日益受到重视。以简单易得的黄烷酮类化合物为起始原料,与水合肼合成关键的活性中间体黄烷酮单腙。随后与一系列的芳香醛、烷基酮等发生缩合反应生成的黄烷酮双腙。在最佳反应条件下,以54%~92%的收率合成了12种不同不对称黄烷酮双腙产物。该反应具有反应条件温和、官能团容忍度高、底物普适性广等优点。Asymmetric dihydrazone compounds process significant biological activities.Commercially available flavanones and hydrazine hydrate were served as the starting materials for the construction of the key intermediate flavanone hydrazones.Then,several flavanone dihydrazones were prepared through the condensation of substituted aromatic aldehydes or aliphatic ketones with the key intermediate flavanone hydrazones.Under the optimal reaction conditions,twelve asymmetric flavanone dihydrazones were synthesized in the yields of 54%~92%.This novel approach featured the advantages of mild reaction conditions,good functional group tolerance and broad substrates scope.

关 键 词：黄烷酮 双腙化合物 绿色合成 结构表征 

分 类 号：O621[理学—有机化学]