Personal PM_(2.5)-bound PAH exposure and lung function in healthy office workers:A pilot study in Beijing and Baoding,China  

作　　者：Xuan Zhang Hao Zhang Yan Wang Pengchu Bai Lulu Zhang Yongjie Wei Ning Tang 

机构地区：[1]Graduate School of Medical Sciences,Kanazawa University,Kakuma-machi,Kanazawa 920-1192,Japan [2]School of Civil Engineering,Architecture and Environment,Hubei University of Technology,Wuhan 430068,China [3]Institute of Nature and Environmental Technology,Kanazawa University,Kakuma-machi,Kanazawa 920-1192,Japan [4]State Key Laboratory of Environmental Criteria and Risk Assessment,Chinese Research Academy of Environmental Sciences,Beijing 100012,China [5]Institute of Medical,Pharmaceutical and Health Sciences,Kanazawa University,Kakuma-machi,Kanazawa 920-1192,Japan

出　　处：《Journal of Environmental Sciences》2023年第11期48-59,共12页环境科学学报（英文版）

基　　金：supported by the Sasakawa Scientific Research Grant(2021-6039)from The Japan Science Society;the Bilateral Open Partnership Joint Research Projects of the Japan Society for the Promotion of Science,Japan(JPJSBP120219914);the CHOZEN Project of Kanazawa University,Japan;the cooperative research programs of the Institute of Nature and Environmental Technology,Kanazawa University,Japan.

摘　　要：The effect of short-term exposure to polycyclic aromatic hydrocarbons(PAHs)on the respiratory system among healthy residents is unclear.Beijing and Baoding are typical polluted cities in China,and there is little research on PAH exposure and its health effects at the individual level.Fourteen healthy female office workers were recruited in urban Beijing and Baoding,China,in 2019.The personal exposure to fine particulate matter(PM_(2.5))-bound PAHs and lung function were seasonally monitored.The relationships between PAH exposure and lung function were determined by a generalized mixed linear model.Subjects were exposed to high levels of PAH,in which the benzo[a]pyrene(BaP)level(1.26 ng/m^(3))was over than Chinese national indoor standard(1 ng/m^(3)).All PAHs concentration was higher in winter than that in summer and autumn.Only benz[a]anthracene(BaA)and chrysene(Chr)exposure showed weak relations with decreased lung function,i.e.,a 0.58% and 0.73% decrease in peak expiratory flow at lag 2 day,respectively(p<0.05).PAHs may not be suitable exposure indicators for short-term change in lung function.Our findings highlight the importance of reducing PAH pollution for public respiratory health protection in heavy-polluted cities of China.This pilot study also provides experience on personal PAH assessment such as estimation of the number of repeated measurements required,which is helpful to determine the relationship between PAH exposure and health effect.

关 键 词：Polycyclic aromatic hydrocarbons Personal exposure Lung function Exposure-response relationship 

分 类 号：R12[医药卫生—环境卫生学] X513[医药卫生—公共卫生与预防医学]