海洋放线菌的研究现状及未来展望  

Research status and prospects of marine actinomycetes

作　　者：徐迦南 王文广[1] 江辉[1] 高启燕 XU Jia’nan;WANG Wenguang;JIANG Hui;GAO Qiyan(College of Life Sciences,Zhejiang University,Hangzhou 310012,Zhejiang,China;Comprehensive Technical Service Center of Taizhou Customs,Taizhou 318001,Zhejiang,China)

机构地区：[1]浙江大学生命科学学院,浙江杭州310012 [2]台州海关综合技术服务中心,浙江台州318001

出　　处：《微生物学通报》2023年第10期4729-4744,共16页Microbiology China

基　　金：国家自然科学基金(31870005)。

摘　　要：【背景】放线菌具有丰富的遗传和功能多样性,其次级代谢产物活性广泛,在临床医疗、农业生产和污染防治等领域都发挥着重要的作用。海洋放线菌由于其特殊的代谢途径,能产生独特的活性天然产物而受到广泛关注。【目的】探究国内外海洋放线菌领域研究的热点和趋势,为后续研究提供参考。【方法】以“marine actinomycetes or marine actinobacteria”为关键词,在Web of Science中检索海洋放线菌领域的文章进行计量分析,使用VOSviewer软件对其关键词、国家、机构、作者、发表时间进行可视化分析。【结果】海洋放线菌领域的文章发表数量总体呈逐年上升趋势,主要集中在微生物学及药学领域,中美两国在论文数量和引用频次上远超其他国家,海洋放线菌领域的研究集中在菌株的分离鉴定、活性天然产物挖掘以及生物信息学等方面。【结论】海洋放线菌在全球范围内愈发受到重视,国内外机构应当加强合作,运用生物信息学技术进一步挖掘活性次级代谢产物,推动海洋放线菌领域进一步发展。[Background]Actinomycetes exhibit rich genetic and functional diversity and produce a wide range of secondary metabolites,which play a role in clinical medicine,agricultural production,and pollution control.Marine actinomycetes have attracted much attention due to their special metabolic pathways and their ability to produce unique active natural products.[Objective]To investigate the research hotspots and future trends of marine actinomycetes and provide reference for subsequent research.[Methods]The articles about marine actinomycetes were retrieved from Web of Science with marine actinomycetes or marine actinobacteria as the keyword for quantitative analysis.VOSviewer was used for the visual analysis of the keywords,countries,institutions,authors,and publishing dates.[Results]The total number of articles about marine actinomycetes was increasing year by year.China and the United States far exceeded other countries in the number of articles and the frequency of citations.The relevant studies focused on the isolation and identification of strains,the mining of active natural products,and bioinformatics.[Conclusion]Marine actinomycetes have attracted increasing attention worldwide.Domestic and overseas institutions should strengthen cooperation and employ bioinformatics to further mine the active secondary metabolites and facilitate the development of marine actinomycetes.

关 键 词：海洋放线菌 文献计量学 天然产物 生物活性 

分 类 号：Q93[生物学—微生物学]