Facile Synthesis of Amino Acid Decorated Water-Soluble Fullerene Derivatives with Anti-influenza Activity  

作　　者：Valeriya S.Bolshakova Ekaterina O.Sinegubova Yana L.Esaulkova Alexander S.Peregudov Ekaterina A.Khakina Nikita A.Slesarenko Alexander F.Shestakov Vladimir V.Zarubaev Pavel A.Troshin Olga A.Kraevaya 

机构地区：[1]Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of RAS,Academician Semenov ave.1,Chernogolovka,142432,Russia [2]Higher Chemical College of RAS,D.1.Mendeleev University of Chemical Technology of Russia,Miusskaya square 9,Moscow,125047,Russia [3]St.Petersburg Pasteur Institute,Mira st.14,St.Petersburg,197101,Russia [4]A.N.Nesmeyanov Institute of Organoelement compounds of RAS,Vavylova St.28,B-334,Moscow,119991,Russia [5]National Research University Higher School of Economics,Vavylova St.7,Moscow,101000,Russia [6]Department of Fundamental Physics&Chemical Engineering,M.V.Lomonosov Moscow State University,Leninskie Gory 1/51,Moscow,119991,Russia [7]Zhengzhou Research Institute,Harbin Institute of Technology,Longyuan East 7th 26,Jinshui District,Zhengzhou,Henan 450003,China [8]Harbin Institute of Technology,West Dazhi Street 92,Nan Gang District,Harbin,Heilongjiang 150001,China

出　　处：《Chinese Journal of Chemistry》2023年第15期1803-1808,共6页中国化学（英文版）

基　　金：Russian Science Foundation(19-13-00411-P);O.A.K.acknowledges the support from the Stipend of the President of Russian Federation(SP-2022).

摘　　要：Comprehensive Summary Herein,we present a facile synthesis of amide-type water-soluble fullerene derivatives decorated with five residues of amino acids.As compared to the previously developed approaches,the proposed method enables usage of a broad range of amino acids,including those unstable under Friedel-Crafts reaction conditions.Furthermore,it is fully tolerant to the nature of the sixth addend X in C60R5X precursor compounds and allows one to obtain fullerene derivatives with X=Cl,H,alkyl.The synthesized amide-type water-soluble fullerene derivatives demonstrated promising antiviral activities against rimantadine-resistant influenzaА/Puerto Rico/8/34(Н1N1)virus in vitro.

关 键 词：FULLERENES Amino acids Regioselectivity Water-solublel Influenza ANTIVIRAL 

分 类 号：TQ460.1[化学工程—制药化工]