某高校教职工人群亚临床甲状腺疾病患病情况及其相关因素分析  

Prevalence of subclinical thyroid disease in the faculty and staff of a university and their affecting factors

作　　者：罗士欢 聂颖 张新焕 白雪 孙亚慧 孔令伟 王一飞 Luo Shihuan;Nie Ying;Zhang Xinhuan;Bai Xue;Sun Yahui;Kong Lingwei;Wang Yifei(Beijing Jiaotong University Community Health Service Center,Beijing 100044,China)

机构地区：[1]北京交通大学社区卫生服务中心,北京100044

出　　处：《中华全科医师杂志》2023年第10期1032-1037,共6页Chinese Journal of General Practitioners

摘　　要：目的了解某高校教职工亚临床甲状腺疾病的患病现状,探讨影响亚临床甲状腺疾病的相关因素。方法本研究为横断面研究。纳入参加2021年度北京交通大学社区卫生服务中心健康体检的满足纳入、排除标准的教职工4219名为研究对象,收集入选者的一般临床资料及实验室检查结果。以本实验室促甲状腺激素(TSH)的正常参考值范围上限(5.5μIU/ml)及下限(0.35μIU/ml)为诊断切点,分为亚临床甲状腺功能亢进(亚临床甲亢)组、亚临床甲状腺功能减退(亚临床甲减)组、甲状腺功能(甲功)正常组。比较不同性别、年龄、体重指数对亚临床甲状腺疾病患病率的影响;采用相关性分析评估亚临床甲状腺疾病与代谢指标的相关性。结果亚临床甲减和亚临床甲亢的患病率分别为4.10%(173/4219)和0.69%(29/4219)。女性亚临床甲状腺疾病患病率高于男性[5.90%(77/2101)比3.66%(125/2018),χ2=11.58,P<0.05],不同年龄组之间患病率差异有统计学意义(χ2=39.49,P<0.05),随着年龄增长,患病率升高。3组受试者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、舒张压、空腹血糖、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)的水平及甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)的阳性率差异均有统计学意义(均P<0.05)。相关性分析结果显示TSH水平分别与年龄、TG、TC、LDL-C、TPOAb、TGAb(r=0.58、0.66、0.67、0.62、0.78、0.77,P<0.05)水平呈正相关,与空腹血糖(r=-0.50,P<0.05)水平呈负相关。结论亚临床甲状腺疾病的患病率较高,需引起重视;亚临床甲状腺疾病的发病与性别、年龄及甲状腺抗体、血糖、血脂水平可能具有相关性。ObjectiveTo investigate the status quo of subclinical thyroid diseases in the faculty and staff of a university and to explore their affecting factors.MethodsA total of 4219 faculty and staff members who met the exclusion criteria and underwent the health examination in the Community Health Service Center of Beijing Jiaotong University in 2021 were enrolled in the study.General clinical data and laboratory findings of the enrolled subjects were collected.According to the upper and low reference range of thyroid stimulating hormone(TSH)in our laboratory(0.35-5.5μIU/ml),subjects were classified into subclinical hyperthyroidism group,subclinical hypothyroidism group and normal thyroidism group.The association of gender,age and body mass index(BMI),as well as the metabolic indices with the prevalence of subclinical thyroid disease was analyzed.ResultsThe prevalence rates of subclinical hypothyroidism and subclinical hyperthyroidism were 4.10%(173/4219)and 0.69%(29/4219),respectively.The prevalence of subclinical thyroid diseases in females was higher than that in males(5.90%(77/2101)vs.3.66%(125/2018),χ2=11.58,P<0.05);there was a significant difference in prevalence among different age groups(χ2=39.49,P<0.05)and the prevalence increased with the age.There were significant differences in levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),diastolic blood pressure(DBP),fasting blood glucose(FBG),free triiodothyronine(FT3),free thyroxine(FT4),thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)among three groups(P<0.05).TSH levels were positively correlated with the age(r=0.58,P<0.001),and levels of TG(r=0.66,P<0.001),TC(r=0.67,P<0.001),LDL-C(r=0.62,P<0.001),TPOAb(r=0.78,P<0.001),TGAb(r=0.77,P<0.001);was negatively correlated with FBG(r=-0.50,P<0.001).ConclusionThe prevalence of subclinical thyroid diseases among faculty and staff of the studied university is relatively high,and it is related to gender,age,thyroid antibodies,blood glucose and lipid levels.

关 键 词：甲状腺疾病 亚临床甲状腺功能减退 亚临床甲状腺功能亢进 影响因素 

分 类 号：R581[医药卫生—内分泌]