巴豆烷型活性大环二萜类化合物的研究进展  

Research progress in tigliane-type macrocyclic diterpenoids

作　　者：谭洪虎 夏梦 苏平[1] 黄璐琦[1,2] TAN Hong-hu;XIA Meng;SU Ping;HUANG Lu-qi(State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]中国中医科学院中药资源中心道地药材品质保障与资源持续利用全国重点实验室,北京100700 [2]南京中医药大学药学院,江苏南京210023

出　　处：《中国中药杂志》2023年第17期4620-4633,共14页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82204568);中央本级重大增减支项目(2060302);中国中医科学院科技创新工程项目(CI2021B014);中国中医科学院基本科研业务费优秀青年科技人才培养专项(ZZ16-YQ-042)。

摘　　要：巴豆烷型二萜是一类结构特殊、生物活性多样的大环二萜类化合物,主要从大戟科和瑞香科植物中提取分离得到。根据分子结构中官能团的差异可以分为佛波酯型、C-4脱氧佛波酯型、C-12脱氧佛波酯型、C-16或C-17取代佛波酯型、其他型。因其多数呈现出良好的抗病毒活性和细胞毒活性,有望开发成为抗艾滋病、抗结核、抗肿瘤等临床试验的候选药物,在医疗卫生领域具有巨大的应用潜力。该文综述了从2013年以来新发现的115个巴豆烷型二萜类化合物,通过对其化学结构和生物活性进行归纳总结,以期为进一步开发利用该类化合物提供参考,同时也为临床新药的研发提供新的思路。Tigliane type macrocyclic diterpenoids with special structures and diverse bioactivities are mainly extracted from plants of Euphorbiaceae and Thymelaeaceae.According to the different functional groups,they can be classified into types of phorbol esters,C-4 deoxyphorbol esters,C-12 deoxyphorbol esters,C-16 or C-17 substituted phorbol esters and others.Most of them present promising antiviral activities and cytotoxic activities and are expected to be developed as candidates for anti-AIDS,anti-tuberculosis,and anti-tumor clinical trials,demonstrating great potential for the application in healthcare.This paper reviews 115 novel tigliane-type diterpenoids discovered since 2013 and summarize their chemical structures and bioactivities,aiming to lay a foundation for further development and utilization of these compounds and provide new ideas for the development of clinical drugs.

关 键 词：巴豆烷型 大环二萜 化学结构 生物活性 新药开发 

分 类 号：R284[医药卫生—中药学]