牛蒡叶中1个新的降碳倍半萜  

A new norsesquiterpenoid from Arctium lappa leaves

作　　者：吕江南 张玲霞[1,2] 杨清宇 黄娜[1,2] 王智民[2,3] 代丽萍[1,2] LYU Jjang-an;HANG Ling-xia;YANG Qing-yu;HUANG Na;WANG Zhi-min;DAI Liping(Henan University of Chinese Medicine,Zhengzhou 450046,China;Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province,Henan University of Chinese Medicine,Zhengzhou 450046,China;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学河南省豫产道地药材综合开发利用工程技术研究中心,河南郑州450046 [3]中国中医科学院中药研究所中药质量控制技术国家工程实验室,北京100700

出　　处：《中国中药杂志》2023年第18期5024-5031,共8页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2017YFC1701904);河南省重大科技专项(221100310400);河南省中医药产业守正创新发展规划研究项目(TCM2021013);2023年度河南省高校科技创新团队项目(23IRTSTHN028)。

摘　　要：采用硅胶、ODS、MCI、Sephadex LH-20等柱色谱分离技术对牛蒡叶乙酸乙酯部位进行化学成分研究。通过NMR、MS、IR、UV、X衍射等现代波谱技术及结合文献数据对分离得到的化合物进行结构鉴定,共鉴定出20个化合物,分别为arctanol(1)、柑橘苷A(2)、melitensin 15-O-β-D-glucoside(3)、11β,13-氢化刺蓟苦素(4)、11β,13-dihydrosalonitenolide(5)、8α-羟基-β-桉叶醇(6)、紫丁香苷(7)、二氢丁香苷(8)、3,4,3′,4′-tetrahydroxy-δ-truxinate(9)、松脂素(10)、连翘脂素(11)、丁香脂素(12)、山柰酚(13)、槲皮素(14)、木犀草素(15)、金丝桃苷(16)、4,5-二咖啡酰奎宁酸(17)、1H-indole-3-carboxaldehyde(18)、苄醇-β-D-葡萄糖苷(19)、N-(2′-苯基乙基)异丁酰胺(20)。其中化合物1为新的降碳倍半萜,化合物2~5、7~8、18~20为首次从牛蒡属中分离得到。Chemical constituents were isolated and purified from ethyl acetate fraction of Arctium lappa leaves by silica gel,ODS,MCI,and Sephadex LH-20 column chromatography.Their structures were identified with multiple spectroscopical methods including NMR,MS,IR,UV,and X-ray diffraction combined with literature data.Twenty compounds(1-20)were identified and their structures were determined as arctanol(1),citroside A(2),melitensin 15-0-β-D-glucoside(3),11β,13-dihydroonopordopicrin(4),11β,13-dihydrosalonitenolide(5),8α-hydroxy-β-eudesmol(6),syringin(7),dihydrosyringin(8),3,4,3',4'-tetrahydroxy-8-truxinate(9),(+)-pinoresinol(10),phillygenin(11),syringaresinol(12),kaeperferol(13),quercetin(14),luteolin(15),hyperin(16),4,5-0-dicaffeoylquinic acid(17),1H-indole-3-carboxaldehyde(18),benzyl-β-D-glucopyranoside(19),and N-(2'-phenylethyl)isobutyramide(20).Among them,compound 1 is a new norsesquiterpenoid,and compounds 2-5,7-8,and 18-20 are isolated from this plant for the first time.

关 键 词：牛蒡叶 降碳倍半萜 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]