多黏菌素耐药mcr基因的研究进展  

Advances in research on polymyxin resistance mcr gene

作　　者：曹兴旺 李益涛 徐道元 付祥益宁 何欣 陈扬 田美卉 王超丽 霍明凯 肖陈城 李亚玲 CAO Xingwang;LI Yitao;XU Daoyuan;FU Xiangyining;HE Xin;CHEN Yang;TIAN Meihui;WANG Chaoli;HUO Mingkai;XIAO Chencheng;LI Yaling(College of Animal Science and Technology,Shihezi University,Shihezi 832000,China;Shihezi Veterinary Association,Shihezi 832000,China)

机构地区：[1]石河子大学动物科技学院,新疆石河子832000 [2]石河子兽医协会,新疆石河子832000

出　　处：《黑龙江畜牧兽医》2023年第19期29-36,共8页Heilongjiang Animal Science And veterinary Medicine

基　　金：第七师-石河子大学科技创新专项;石河子大学青年创新人才计划项目(CXBJ202202);广东省科技计划项目(2021B1212030015)。

摘　　要：多黏菌素是治疗多重耐药革兰氏阴性菌感染的“最后一道防线”,然而质粒介导的多黏菌素抗性基因mcr-1及其变异体在全球传播,给畜牧业健康发展和人类公共卫生安全带来了严重挑战。文章综述了mcr-1基因的发现、结构和流行情况,mcr-1基因变异体、流行特征以及防治策略等的研究进展,以期为相关科研人员和临床工作者提供参考,共同应对抗生素耐药日益严峻的局面。Polycolistin is the‘last line of defense’against multi-drug-resistant gram-negative infections.However,the global spread of plasmid-mediated polycolistin resistance gene mcr-1 and its variants has brought serious challenges to the healthy development of animal husbandry and human public health security.In this paper,the discovery,structure and prevalence of mcr-1 gene,mcr-1 gene variants,their epidemic characteristics and prevention strategies were reviewed,in order to provide reference for relevant researchers and clinical workers to jointly deal with the increasingly severe situation of antibiotic resistance.

关 键 词：mcr-1基因 多黏菌素 耐药性 肠杆菌科 质粒 

分 类 号：S859.796[农业科学—临床兽医学]