心脏缺血再灌注损伤与线粒体质量控制  

Cardiac ischemia-reperfusion injury and mitochondrial quality control

作　　者：黄琪惠 华天凤[1,2] 杨旻(审校)[1,2] HUANG Qihui;HUA Tianfeng;YANG Min(Second Department of Critical Care Medicine,the Second Affiliated Hospital of Anhui Medical University,Hefei,230601,China;Cardiopulmonary Resuscitation and Critical Care Laboratory,the Second Affiliated Hospital of Anhui Medical University)

机构地区：[1]安徽医科大学第二附属医院重症医学二科,合肥230601 [2]安徽医科大学第二附属医院心肺复苏与危重病实验室

出　　处：《临床急诊杂志》2023年第9期443-447,共5页Journal of Clinical Emergency

摘　　要：心脏缺血再灌注(ischemia-reperfusion,I/R)损伤是心脏疾病中常见并发症,其发生机制复杂且尚未完全阐明。线粒体质量控制(mitochondrial quality control,MQC)是维持心肌细胞正常功能和适应能力的关键过程。MQC系统参与调节线粒体生物合成、线粒体动力学以及自噬环节,保护心肌细胞免受I/R损伤的影响。目前,MQC成为心脏I/R损伤的新型靶向治疗策略。本文通过概述MQC与心脏I/R损伤之间的联系及近期研究机制进展,旨在提供新的思路和研究方向,为心脏疾病的治疗和预防提供理论依据。Cardiac ischemia-reperfusion(I/R)injury is a prevalent complication of cardiac diseases,mechanism of which remains intricate and incompletely understood.Mitochondrial quality control(MQC)is a key process in maintaining the normal function and adaptability of cardiomyocytes.The MQC system orchestrates mitochondrial biosynthesis,dynamics,and autophagy,affording protection against I/R injury.At present,MQC has become a new targeted treatment strategy for cardiac I/R injury.By summarizing the relationship between MQC and cardiac I/R injury and the recent research mechanism,this paper aims to provide new ideas and research directions,and provide theoretical basis for the treatment and prevention of heart diseases.

关 键 词：心脏缺血再灌注损伤 线粒体质量控制 线粒体动力学 线粒体自噬 

分 类 号：R285.5[医药卫生—中药学]