外阴鳞状细胞癌手术预后列线图模型建立  

Establishment of Nomogram models for surgical prognosis in patients with vulva squamous cell carcinoma.

作　　者：曹郑芳 陈小斌 陈炜璐 柴培建 刘本杰[1] Cao Zhengfang;Chen Xiaobin;Chen Weilu(Department of Obstetrics and Gynecology,People's Hospital of Pujiang County,Jinhua 322200;Department of Gynecology,Women's Hospital,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology,Hangzhou 310000;Department of Obstetrics and Gynecology,Zhuji Maternal and Child Health Hospital,Zhuji 311800)

机构地区：[1]浙江省浦江县人民医院妇产科,金华322200 [2]浙江大学医学院附属妇产科医院妇科,浙江省妇产疾病临床医学研究中心,杭州310000 [3]诸暨市妇幼保健院妇产科,诸暨311800 [4]宁海县妇幼保健院妇产科,宁波315600

出　　处：《现代妇产科进展》2023年第10期733-736,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:建立外阴鳞癌手术后生存时间列线图模型,评估其生存率。方法:回顾分析SEER数据库中2607例诊断为外阴鳞癌的手术后患者,Cox比例风险回归模型单因素及多因素分析筛选独立危险因素。构建3年生存率和5年生存率的列线图模型,ROC曲线及校准图对模型进行检验,生存曲线评估其生存时间。结果:Cox回归模型结果表明,年龄、组织学分级、AJCC分期是外阴鳞癌手术后患者预后的独立因素。R语言建立3年和5年的生存率列线图模型,能有效评估患者3年和5年预后的生存率。ROC曲线结果表明,该列线图模型区分度较好。校准图结果表明该列线图模型校准能力较好。生存曲线提示AJCC分期中Ⅳb期预后最差。结论:列线图模型有助于对手术后外阴鳞癌预后生存率进行临床评估。Objective:The nomogram models of survival time in patients with vulvar squamous cell carcinoma was established to evaluate the survival rate.Methods:A retrospective analysis of 2607 patients were diagnosed as squamous cell carcinoma of vulva after surgery in SEER database.The Cox regression model was used to screen independent risk factors.The nomogram model of 3-year and 5-year survival rate was constructed,and the ROC curve and calibration chart were used to test the nomogram model.The survival curve was used to evaluate the survival time.Results:The Cox regression model showed that age,histological grade and AJCC stage were independent prognostic factors of patients with vulvar squamous cell carcinoma after surgery.The nomogram model of 3-year and 5-year survival rate were established by R language which could effectively evaluate the 3-year and 5-year survival rate of patients.ROC curve results indicated that the nomogram model had good discrimination.The calibration results demonstrated that the nomogram model had good calibration ability.The survival curve suggested thatⅣb stage had the worst prognosis in AJCC stage.Conclusion:The nomogram model is helpful to evaluate the survival rate in patients with vulvar squamous cell carcinoma after surgery.

关 键 词：外阴鳞状细胞癌 COX回归模型 列线图 生存率 

分 类 号：R71[医药卫生—妇产科学]