老年空腹血糖受损患者远期进展为2型糖尿病风险影响因素及预测指标探讨  

Risk factors of long-term progression to T2DM in elderly patients with IFG and predictors

作　　者：焦建虎 刘新琼 侯瑜 雷婷 向惠敏 刘洋 Jiao Jianhu;Liu Xinqiong;Hou Yu;Lei Ting;Xiang Huimin;Liu Yang(Department of Endocrinology,Tongchuan People′s Hospital,Shaanxi 727100,China;不详)

机构地区：[1]陕西省铜川市人民医院内分泌科,727100 [2]陕西省铜川矿务局中心医院内分泌科

出　　处：《山西医药杂志》2023年第17期1299-1303,共5页Shanxi Medical Journal

摘　　要：目的探讨老年空腹血糖受损(IFG)患者随访进展为2型糖尿病(T2DM)的影响因素。方法回顾性分析2016年1月至2017年1月于我院体检证实存在IFG老年患者共656例临床资料,根据随访36个月是否进展为T2DM分组,其中进展和未进展分别为112例、544例,分析2组基线临床特征资料,采用Logistic多元回归模型分析老年IFG患者随访进展为T2DM独立影响因素,描绘受试者工作特征(ROC)曲线评价相关指标预测价值。结果T2DM组体质指数(BMI)水平、空腹血糖(FBG)水平及跌倒史比例均高于非T2DM组(P<0.05);T2DM组握力体质指数、4 m步行测试均低于非T2DM组(P<0.05);多因素分析结果显示,BMI、握力体质指数、4 m步行测试、FBG、总胆固醇(TC)及跌倒史是老年IFG患者随访进展为T2DM独立影响因素(P<0.05);ROC曲线分析结果显示,FBG和握力体质指数均可用于老年IFG患者远期进展为T2DM风险预测,曲线下面积(AUC)分别为0.75、0.70。结论老年IFG患者随访进展为T2DM与BMI、握力体质指数、4 m步行测试、FBG、TC及跌倒史密切相关;FBG和握力体重指数均可用于该类患者随访进展为T2DM风险预测。Objective To investigate the risk factors of long-term progression to type 2 diabetes mellitus(T2DM)in elderly patients with impaired fasting glucose(IFG)and predictors.Methods Clinical data of 656 elderly patients with IFG were retrospectively chosen in the period from January 2016 to January 2017.All patients were divided into different groups according to whether patients with progression to T2DM with 36 months follow-up.The baseline clinical characteristics and the independent influencing factors of follow-up progress of elderly IFG patients with T2DM were analyzed by Logistic multiple regression model.The ROC curve was drawn to evaluate the predictive value of relevant indicators.Results The levels of body mass index(BMI),FBG,and fall history in T2DM group were significantly more than non-T2DM group(P<0.05).The body mass index of grip strength and 4th walking test in T2DM group was significantly less than non-T2DM group(P<0.05).Multivariate analysis showed that BMI,grip mass index,walking speed,fasting blood glucose(FBG),total cholesterol(TC)and fall history were independent influencing factors of progression to T2DM with follow-up in elderly patients with IFG(P<0.05).ROC curve analysis showed that FBG and grip strength body mass index could be used to predict the risk of long-term progression to T2DM in elderly IFG patients,and AUC were 0.75 and 0.70 respectively.Conclusion Progression to T2DM with follow-up in elderly patients with IFG are closely related to BMI,grip mass index,walking test,FBG,TC and fall history.FBG and grip strength body mass index can be used to predict the risk of progression to T2DM with follow-up.

关 键 词：老年人 糖尿病 2型 葡萄糖耐受不良 影响因素分析 预测 

分 类 号：R587.1[医药卫生—内分泌]