中国人群中血脂成分与血尿酸间的剂量-反应关系  

Dose-response association between lipid profiles and serum urate acid in Chinese adults

作　　者：高倩 李婷[1,2] 彭刘庆 王彤[1,2] GAO Qian;LI Ting;PENG Liuqing;WANG Tong(Department of Health Statistics,School of Public Health,Shanxi Medical University,Taiyuan 030001,China;Key Laboratory of Coal Environmental Pathogenicity and Prevention,Ministry of Education,Taiyuan 030001,China)

机构地区：[1]山西医科大学公共卫生学院卫生统计学教研室,太原030001 [2]煤炭环境致病与防治教育部重点实验室,太原030001

出　　处：《中华疾病控制杂志》2023年第10期1140-1145,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(82204163,82073674);山西省基础研究计划资助项目(202203021212382)。

摘　　要：目的探讨中国成人血脂成分与血尿酸(serum uric acid,SUA)间的剂量-反应关系,为高尿酸血症(hyperuricemia,HUA)的防治提供理论依据。方法基于中国健康与营养调查(China Health and Nutrition Survey,CHNS)2009年和中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)2011-2012年的调查数据,分别纳入符合研究纳入排除标准的研究对象8509名和6749名。采用广义倾向性评分逆概率加权方法,均衡年龄、性别等潜在混杂因素后,估计血脂成分总胆固醇(cholesterol,TC)、低密度脂蛋白(low-density lipoprotein,LDL)、高密度脂蛋白(high-density lipoprotein,HDL)和三酰甘油(triglycerides,TG)与SUA间的剂量-反应关系。结果CHNS和CHARLS研究对象的平均年龄分别为(50.32±15.08)岁和(58.52±9.17)岁,SUA升高者分别占15.30%和5.34%。在均衡可能的混杂因素后,逆概率加权法分析结果显示,TG和HDL与SUA间存在统计学剂量-反应关系,SUA水平随TG水平的升高和HDL水平的降低而升高。结论血脂异常可能导致SUA升高,及时调节血脂水平可能有助于HUA的防治。Objective This study aims to estimate dose-response relationship of lipid profiles on serum urate acid(SUA),and to provide evidence for prevention and therapy of Hyperuricemia(HUA).Methods Based on China Health and Nutrition Survey(CHNS)in 2009 and China Health and Retirement Longitudinal Study(CHARLS)in 2011-2012,8509 and 6749 participants with no missing key variables were included in this study,respectively.Generalized propensity score based inverse probability weighting(IPW)method was used to adjust for potential confounders,and to estimate dose-response curves of total cholesterol(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),and triglycerides(TG)on SUA.Results In CHNS,the mean age was(50.32±15.08)years old with 15.3%of individuals having high levels of SUA.In CHARLS,the mean age was(58.52±9.17)years old and,5.34%of individuals had high levels of SUA.Results of IPW analysis showed that there were statistically significant dose-response relationship between TG,HDL and SUA in both CHNS and CHARLS.The SUA increased as TG increased and HDL decreased.Conclusions The abnormality of lipid profiles may lead to an increase in SUA,and the timely lipid-modifying may help to prevent and treat HUA.

关 键 词：血脂成分 血尿酸 高尿酸血症 剂量-反应关系 广义倾向性评分逆概率加权法 

分 类 号：R181.3[医药卫生—流行病学] R589[医药卫生—公共卫生与预防医学]