寄生虫感染中TGF-β/Smad信号通路参与调控宿主T细胞免疫应答的研究进展  

Research progress on the influence of TGF-β/Smad signaling pathway on host T cell immune responses in parasite infection

作　　者：孙晓晴 何威 周必英 Sun Xiaoqing;He Wei;Zhou Biying(Department of Parasitology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学寄生虫学教研室,遵义563000

出　　处：《中华地方病学杂志》2023年第9期758-762,共5页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81960378);贵州省科技厅基础研究计划(黔科合基础-ZK[2023]一般516)。

摘　　要：寄生虫感染是全球重要的公共卫生问题,寄生虫可以通过各种方式调节和逃避宿主免疫攻击。近年来研究表明,寄生虫感染过程中,转化生长因子-β(transforming growth factor-β,TGF-β)/Smad信号通路可参与宿主T细胞免疫应答,诱导T细胞向调节性T细胞(regulatory cell,Treg)、辅助性T细胞(helper T cell,Th)增殖与分化,调控Treg/Th17细胞平衡,抑制Th1细胞增殖分化,在寄生虫病的发生发展及其与宿主的相互作用中起重要作用。本文就寄生虫感染过程中TGF-β/Smad信号通路参与调控T细胞免疫应答的研究进展进行综述。Parasitic infection are an important global public health issue,and parasites can modulate and evade host immune attacks through various ways.In recent years,studies have shown that in the process of parasite infection,transforming growth factor-β(TGF-β)/Smad signaling pathway participates in host T cell immune response,induce T cells to proliferate and differentiate towards regulatory cells(Treg)and helper T cells(Th),regulate Treg/Th17 cell balance,inhibit Th1 cell proliferation and differentiation,and play an important role in the occurrence and development of parasitic diseases and their interactions with the host.This article reviews the research progress of T cell immune responses mediated by TGF-β/Smad signaling pathway in the process of parasite infection.

关 键 词：寄生虫 T细胞 免疫应答 TGF-Β/SMAD信号通路 

分 类 号：R53[医药卫生—内科学]