美国在非洲猪瘟病毒基因缺失疫苗研究中的路线及进展  

Research Route and Progress on African Swine Fever Virus Gene Deletion Vaccine in the United States

作　　者：韩乃君 徐天刚[1,3] 戈胜强 左媛媛[1] 胡永新 屈海龙[1] 吴晓东 王志亮 HAN Najun;XU Tiangang;GE Shengqiang;ZUO Yuanyuan;HU Yongxin;QU Hailong;WU Xiaodong;WANG Zhilang(China Animal Health and Epidemiology Center,Qingdao 266032,China;Qingdao Key Laboratory of Modern Bioengineering and Animal Disease Research,Qingdao 266032,China;Key Laboratory of Animal Biosafety Risk Prevention and Control(South),Ministry of AgricultureandRuralAffairs,P.R.China,Qingdao 266032,China)

机构地区：[1]中国动物卫生与流行病学中心,青岛266032 [2]青岛市现代生物工程及动物疫病研究重点实验室,青岛266032 [3]农业农村部动物生物安全风险预警及防控重点实验室(南方),青岛266032

出　　处：《病毒学报》2023年第5期1496-1505,共10页Chinese Journal of Virology

基　　金：国家重点研发计划项目(2022YFD1800500),题目:重大外来动物疫病阻断与防控技术研发~~。

摘　　要：非洲猪瘟病毒疫苗研发是公认的世界性难题,近年来,随着生物信息学技术不断发展和基因操作技术的日趋成熟,通过基因敲除方式制备非洲猪瘟弱毒疫苗的研发路线已经初现曙光,相关研究成果不断涌现,特别是美国科研团队在该领域已取得许多积极成果。鉴于国内尚无对美国相关工作的详细报道,本文拟就其研究策略及进展进行综述,以期为我国科研人员开展非洲猪瘟疫苗研究提供借鉴和参考。The research and development of African swine fever vaccine is recognized as a worldwide problem.In recent years,with continuous development of bioinformatics technology and gene manipulation technology,the strategy of preparing African swine fever attenuated vaccine through gene knockout showed some breakthroughs,and relevant research results keep emerging,especially the American research team has made many positive achievements in this field.In view of the lack of detailed reports about the related work in the United States,this paper summarizes the research strategies and progress,in order to provide reference for Chinese researchers to carry out research on ASFV vaccine.

关 键 词：非洲猪瘟病毒 基因操作 基因缺失活疫苗 

分 类 号：R373.9[医药卫生—病原生物学]