壮医经筋疗法治疗单纯性肥胖的疗效和机理研究  

Efficacy and Mechanism of Meridian Sinew Therapy of Zhuang Medicine in Treatment of Simple Obesity

作　　者：朱露露 陈思雨 农雅萍 孙梅梅 赵炬禹 黄思敏 兰蕾 ZHU Lulu;CHEN Siyu;NONG Yaping;SUN Meimei;ZHAO Juyu;HUANG Simin;LAN Lei(Guangxi University of Chinese Medicine,Nanning 530001,China;International Zhuang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530201,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学附属国际壮医医院,广西南宁530201

出　　处：《针灸临床杂志》2023年第10期12-17,共6页Journal of Clinical Acupuncture and Moxibustion

基　　金：广西自然科学基金面上项目,编号:2018GXNSFAA050148;广西中医药管理局适宜技术推广基金,编号:GZSY21-42;广西国际壮医医院引进人才科研启动基金,编号:GZ2021RC010。

摘　　要：目的:观察壮医经筋疗法治疗单纯性肥胖的临床疗效并探究其机理。方法:将66例患者随机分为经筋疗法组和传统疗法组,每组均33例,最终经筋疗法组完成31例,传统疗法组完成32例。经筋疗法组采用壮医经筋疗法治疗,方法包括经筋推拿解结、经筋针刺解结和拔罐解结;传统疗法组采用传统针刺和拔罐治疗。比较两组治疗前后及随访时的中医证候积分和肥胖程度,检测治疗前后血清中脂肪细胞因子和炎症因子含量。结果:经筋疗法组总有效率93.55%(29/31),传统疗法组总有效率71.88%(23/32)(P<0.05)。比较两组的中医证候积分、体重指数(BMI)、体质量、腰围、腰臀比(WHR)和体脂率(F%),治疗后及随访时均较治疗前降低,差异有统计学意义(P<0.05),经筋疗法组与传统疗法组比较差异具有统计学意义(P<0.05);两组瘦素、游离脂肪酸(FFA)、丝氨酸蛋白酶抑制剂(Vaspin)、抵抗素、白介素-1β(IL-1β)、白介素-6(IL-6)和瘤坏死因子-α(TNF-α)均低于治疗前,差异有统计学意义(P<0.05),脂联素高于治疗前,差异有统计学意义(P<0.05),经筋疗法组与传统疗法组比较,差异具有统计学意义(P<0.05)。结论:经筋疗法可改善单纯性肥胖患者肥胖程度,调节脂肪细胞活性因子和改善糖脂代谢,抑制炎症微状态。Objective:To observe the clinical effect of meridian sinew therapy of Zhuang medicine in treatment of simple obesity and to explore its mechanism.Methods:66 patients were randomly divided into the treatment group and the control group,with 33 cases in each group.Finally,31 cases were completed in the treatment group and 32 cases in the control group.The treatment group was treated with meridian sinew therapy of Zhuang medicine,including massage resolving knot,acupuncture resolving knot and cupping resolving knot.The control group was treated with traditional acupuncture and cupping.TCM syndrome score and obesity index were compared among before the treatment,after the treatment and during the follow-up in the two groups.The serum contents of fatty cytokine and inflammatory factors were detected before and after the treatment in the two groups.Results:The total effective rate was 93.55%(29/31)in the treatment group,which was higher than 71.88%(23/32)in the control group(P<0.05).The TCM syndrome score,the body mass index(BMI),the body mass,the waist circumference,the waist-hip ratio(WHR)and the body fat rate(F%)were lower after the treatment and during the follow-up than those before the treatment in the two groups(P<0.05);in which there were statistical differences between the two groups(P<0.05).The levels of leptin,free fatty acid(FFA),Vaspin,resistin,interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower(P<0.05),and adiponectin was higher after the treatment than those before the treatment in the two groups(P<0.05);of which the changes were more significant in the treatment group than those in the control group(P<0.05).Conclusion:Meridian sinew therapy can improve the degree of obesity,adjust fat cell activity factors,ameliorate glucose and lipid metabolisms,and inhibit inflammation in treatment of simple obesity.

关 键 词：壮医经筋疗法 单纯性肥胖 形态学 炎性因子 脂肪细胞活性因子 

分 类 号：R246.1[医药卫生—针灸推拿学]