抗抑郁药治疗青少年抑郁症伴自杀意念的患者的甲状腺激素水平  

Effect of antidepressants on thyroid hormone level in adolescent depression with suicidal ideation

作　　者：张佳俐 王小泉[2] 徐慧[2] 王祖森[2] 汪莲籽 陈方方 杨涛 ZHANG Jiali;WANG Xiaoquan;XU Hui;WANG Zusen;WANG Lianzi;CHEN Fangfang;YANG Tao(Wannan Medical College,Wuhu,Anhui 241000,China;The Fourth People's Hospital of Wuhu City,Wuhu,Anhui 241000,China)

机构地区：[1]皖南医学院,安徽芜湖241000 [2]芜湖市第四人民医院,安徽芜湖241000

出　　处：《上海预防医学》2023年第8期786-790,共5页Shanghai Journal of Preventive Medicine

基　　金：安徽省神经精神疾病与心理健康协同开放性课题项目(NDMHCI-16-08);安徽省芜湖市卫生健康委员会科研项目(WHWJ2021y071);安徽省芜湖市第四人民医院院内课题(kjxm2020-02,kjxm2020-08)。

摘　　要：【目的】比较伴与不伴自杀意念青少年首发抑郁症患者的甲状腺激素水平差异,探讨甲状腺激素与其自杀意念间关联性及抗抑郁药治疗变化。【方法】选取2020年9月—2022年7月精神专科医院100例首发抑郁症青少年患者,将100例患者依据自杀意念量表(SIOSS)列为非自杀意念(n=52)和自杀意念组(n=48)。比较两组在一般人口学资料、促甲状腺激素(TSH)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲腺原氨酸(FT3)和游离甲状腺素(FT4)水平上的差异、甲状腺激素水平与HAMD-17评分的相关性、抗抑郁药治疗6周后激素水平的变化。【结果】非自杀意念组在FT3、FT4、T4水平上均比自杀意念组高;经抗抑郁药治疗6周后,自杀意念组治疗后的FT3、FT4、T4水平均比治疗前高;男性非自杀意念组的FT3水平比自杀意念组高;女性非自杀意念组的FT4、T4水平比自杀意念组高(均P<0.05)。【结论】伴与不伴自杀意念青少年首发抑郁症患者的甲状腺激素水平上存在差异且伴自杀意念的患者经抗抑郁药治疗后有明显变化。[Objective] To compare the differences in thyroid hormone levels between adolescents with and without suicidal ideation,and to explore the association between thyroid hormone/suicidal ideation and the antidepressant treatment.[Methods] A total of 100 patients were divided into non-suicidal ideation group and suicidal ideation group according to the SIOSS.The levels of thyroid-stimulating hormone(TSH),triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3) and free thyroxine(FT4) were compared between the two groups as well as their changes after 6 weeks of antidepressant treatment.[Results] The levels of FT3,FT4 and T4 in the non-suicidal ideation group were higher than those in the suicidal ideation group.After 6 weeks of antidepressant treatment,the levels of FT3,FT4 and T4 in the suicide ideation group were higher than those before the treatment.The FT3 level in the male non-suicidal ideation group was higher than that in the suicidal ideation group.The levels of FT4 and T4 in the female non-suicidal ideation group were higher than those in the suicidal ideation group(all P<0.05) [Conclusion] There are differences in thyroid hormone levels between adolescents with and without suicidal ideation(both with first-episode depression),and patients with suicidal ideation have significant changes after treatment with antidepressants.

关 键 词：青少年 抑郁症 自杀意念 甲状腺激素 抗抑郁药 

分 类 号：R179[医药卫生—妇幼卫生保健] R749.4[医药卫生—公共卫生与预防医学]