多囊卵巢综合征患者多普勒超声测量参数与性激素、炎性因子水平的相关性分析  

Correlation analysis of Doppler ultrasonography parameters with serum levels of sex hormones and inflammatory factors in patients with polycystic ovary syndrome

作　　者：赵芳园[1] 邹红[1] 时思毛[2] 徐芳[2] ZHAO Fang-yuan;ZOU Hong;SHI Si-mao;XU Fang(Department of Ultrasound Medicine,The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China;Department of Gynecology,The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学附属第一医院超声医学科,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科,黑龙江哈尔滨150040

出　　处：《生物医学工程与临床》2023年第5期594-598,共5页Biomedical Engineering and Clinical Medicine

基　　金：黑龙江省中医药科研项目(2018-064);国家自然科学基金资助项目(82004401)。

摘　　要：目的探究多囊卵巢综合征(PCOS)患者多普勒超声测量参数与其性激素、炎性因子水平的相关性。方法选择PCOS患者120例(病例组),年龄23~35岁,平均年龄30.69岁。另取同期在医院体检健康女性100例(对照组),年龄22~35岁,平均年龄30.25岁。给予两组多普勒超声检查,测量两组子宫、卵巢血流参数[阻力指数(RI)、搏动指数(PI)],并取肘静脉血检测其性激素[雌二醇(E2)、促卵泡激素(FSH)、促黄体生成素(LH)、睾酮(T)]及炎性因子[肿瘤坏死因子(TNF)-α、白细胞介素6(IL-6)、内皮抑素(ES)]水平,分析PCOS患者多普勒超声血流参数与其血清炎性因子、性激素水平的相关性。结果两组超声参数比较,病例组子宫RI、PI显著高于对照组(0.89±0.14 vs 0.81±0.12、2.87±0.26 vs2.14±0.21。P<0.05),卵巢RI、PI显著低于对照组(0.43±0.07 vs 0.62±0.12、0.73±0.11 vs 0.91±0.14。P<0.05)。病例组血清LH、T水平显著高于对照组[(9.33±1.64)U/L vs(4.59±1.02)U/L、(1.14±0.13)ng/mL vs(0.61±0.08)ng/mL。P<0.05],FSH水平显著低于对照组[(6.31±1.02)U/L vs(8.96±1.28)U/L。P<0.05],E2水平差异无统计学意义(P>0.05)。病例组血清TNF-α、IL-6、ES均显著高于对照组[(20.95±3.05)ng/mL vs(12.52±2.51)ng/mL、(12.54±1.57)ng/mL vs(6.33±1.05)pg/mL、(234.25±16.33)μg/L vs(156.97±17.05)μg/L。P<0.05]。PCOS患者子宫RI、PI与患者LH、T水平正相关(r=0.531、0.433、0.371、0.407,均P<0.05),与FSH水平负相关(r=-0.963、-1.081,P<0.05);卵巢RI、PI与患者血清LH、T水平负相关(r=-2.082、-1.214、-1.530、-1.094,均P<0.05),与FSH水平正相关(r=0.392、0.583,均P<0.05);PCOS患者子宫RI、PI与血清TNF-α、IL-6、ES均为正相关(r=0.364、0.561、0.385、0.269、0.312、0.405,均P<0.05),卵巢RI、PI与血清TNF-α、IL-6、ES均为负相关(r=-2.634、-3.397、-1.482、-0.398、-1.433、-2.317,均P<0.05)。结论PCOS患者普遍存在子宫及卵巢血流动力学异常,并伴有炎性因子及部分性激素水平高�Objective To explore the correlation between Doppler ultrasound measurement parameters and serum levels of sex hormones and inflammatory factors in patients with polycystic ovary syndrome(PCOS).Methods A total of 120 patients with PCOS were enrolled as case group,which aged 23-35 years old with mean age of 30.69 years old.At the same period,100 healthy examined females were set as control group,aged 22-35 years old with mean age of 30.25 years old.All of them performed Doppler ultrasonography to measure uterine and ovarian blood flow parameters[resistance index(RI),pulsatility index(PI)],and underwent elbow venous blood examination to detect serum levels of sex hormone[estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T)]and inflammatory factors[tumor necrosis factor(TNF)-α,interleukin-6(IL-6),endostatin(ES)]levels.The correlation between Doppler ultrasound blood flow parameters and serum inflammatory factors as well as sex hormone levels in PCOS patients was analyzed.Results The uterine RI and PI in case group were significantly higher than those in control group(0.89±0.14 vs 0.81±0.12,2.87±0.26 vs 2.14±0.21.P<0.05),while ovarian RI and PI in case group were significantly lower than in control group(0.43±0.07 vs 0.62±0.12,0.73±0.11 vs 0.91±0.14.P<0.05).The levels of serum LH and T in case group were significantly higher than those in control group[(9.33±1.64)U/L vs(4.59±1.02)U/L,(1.14±0.13)ng/mL vs(0.61±0.08)ng/mL.P<0.05],while FSH level of in case group was significantly lower than that of control group[(6.31±1.02)U/L vs(8.96±1.28)U/L.P<0.05],and there was no significant difference in E2(P>0.05).The serum levels of TNF-α,IL-6 and ES in case group were significantly higher than those in control group[(20.95±3.05)ng/mL vs(12.52±2.51)ng/mL,(12.54±1.57)pg/mL vs(6.33±1.05)pg/mL,(234.25±16.33)μg/L vs(156.97±17.05)μg/L.P<0.05].The uterine RI and PI of PCOS patients were positively significantly correlated with LH and T levels(r=0.531,0.433,0.371,0.407,P<0.05),

关 键 词：多囊卵巢综合征 多普勒超声 性激素 炎性因子 相关性分析 

分 类 号：R711.75[医药卫生—妇产科学] R445.1[医药卫生—临床医学]