肾损伤标志物N-乙酰-β-D-氨基葡萄糖苷酶检测方法的研究进展  

Renal Injury Marker N-acetyl-β-D-glucosaminidase Research Progress in Detection Methods

作　　者：李志恒 徐瑞平 王思懿 肖炳坤 杨建云 缪潇瑶 黄荣清 LI Zhi-heng;XU Rui-ping;WANG Si-yi;XIAO Bing-kun;YANG Jian-yun;MIAO Xiao-yao;HUANG Rong-qing(Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;College of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 511436,China)

机构地区：[1]军事科学院军事医学研究院辐射医学研究所,北京100850 [2]广东药科大学中药学院,广州511436

出　　处：《科学技术与工程》2023年第29期12347-12353,共7页Science Technology and Engineering

基　　金：北京市自然科学基金(7172161)。

摘　　要：药物引起的肾损伤是一个备受关注的公共健康问题,目前对于早期肾损伤的临床诊断缺少有效的技术手段,导致疾病不能得到及时治疗,最终危及患者的生命安全。N-乙酰-β-D-氨基葡萄糖苷酶(N-acetyl-β-D-glucosaminidase,NAG)是一种新型的肾脏损伤的生物标志物,在早期肾损伤时尿液中的NAG活度即可发生显著变化,因此,开发NAG的精确、批量、低成本检测技术,对于肾脏疾病的早期诊断和治疗具有重大意义。为此,中外学者在近几十年内做了大量的研究工作。综述了NAG检测方法的研究进展,分析了各种方法的优势和不足,最后讨论了NAG检测技术的发展方向。Drug induced renal injury is a public health issue that has received much attention.Currently,there is a lack of effective technical means for the clinical diagnosis of early renal injury,leading to the failure of timely treatment of the disease,ultimately endangering the life safety of patients.N-acetyl-β-D-glucosaminidase(NAG) is a new type of biomarker for renal injury,and the activity of NAG in urine can significantly change during early renal injury.Therefore,the development of accurate,batch,and low-cost detection techniques for NAG is of great significance for the early diagnosis and treatment of kidney diseases.Therefore,scholars have done a lot of research work in recent decades.The research progress of NAG detection methods was summarized,the advantages and disadvantages of various methods was analyzed,and finally the development direction of NAG detection technology was discussed.

关 键 词：N-乙酰-Β-D-氨基葡萄糖苷酶 生物标志物 肾损伤 检测方法 研究进展 

分 类 号：Q55[生物学—生物化学]