硫酸镁与硝苯地平联合治疗对妊高征患者血压水平和母婴结局观察  

Observation on Blood Pressure Level and Maternal and Infant Outcome of Patients with Pregnancy-induced Hypertension Treated with Magnesium Sulfate Combined with Nifedipine

作　　者：许碧雨 柯乳香 XU Biyu;KE Ruxiang(Zhangpu County Maternal and Child Health Hospital,Zhangzhou 363200,China)

机构地区：[1]漳州市漳浦县妇幼保健院,福建漳州363200

出　　处：《中国医药指南》2023年第29期94-96,100,共4页Guide of China Medicine

摘　　要：目的 探究硫酸镁与硝苯地平联合治疗对妊高征患者血压水平和母婴结局的影响。方法 选取妊高征患者100例,时间范围为2020年1月至2022年12月,地点为漳州市漳浦县妇幼保健院,随机将其分为对照组(硫酸镁治疗)和观察组(硫酸镁+硝苯地平治疗),各50例,判定两组临床疗效差异。结果 在SBP、DBP、24 h尿蛋白定量水平方面,治疗后观察组低于对照组,在ET-1、HCT、血浆黏度水平方面,治疗后观察组更低,在NO水平方面,治疗后观察组更高,在不良母婴结局发生率方面,观察组更低(P <0.05)。结论 予以妊高征患者硝苯地平、硫酸镁联合治疗效果显著,体现在提高血压控制效果、降低尿蛋白水平、改善血管内皮功能、调节血液流变学指标、减少不良母婴结局等方面。Objective To explore the effect of magnesium sulfate combined with nifedipine on blood pressure level and maternal and infant outcomes in patients with pregnancy-induced hypertension.Methods 100 patients with pregnancy-induced hypertension were randomly divided into control group(treated with magnesium sulfate) and observation group(treated with magnesium sulfate and nifedipine),with 50 cases in each group,and the difference of clinical efficacy between the two groups was determined.Results After treatment,the quantitative levels of SBP,DBP and 24h urinary protein in the observation group were lower than those in the control group,while the levels of ET-1,HCT and plasma viscosity in the observation group were lower.In terms of NO level,the observation group was higher,and the incidence of adverse maternal and infant outcomes was lower(P<0.05).Conclusions The combined treatment effect of nifedipine and magnesium sulfate in patients with pregnania is significant,which is shown in improving blood pressure control effect,reducing urinary protein level,improving vascular endothelial function,regulating hemorheology indexes,reducing adverse maternal and infant outcomes,etc.

关 键 词：妊高征 硝苯地平 硫酸镁 血压水平 母婴结局 

分 类 号：R714.24[医药卫生—妇产科学]