脓毒症性凝血功能紊乱的精准识别  

Precise identification of sepsis-induced coagulation disorders

作　　者：宋景春 Song Jingchun(Department of Critical Care Medicine,the 908th Hospital of Chinese Logistical Support Force/Nanchang Key Laboratory of Thrombosis and Hemostasis,Nanchang 330002,China)

机构地区：[1]解放军联勤保障部队第九〇八医院重症医学科/南昌市血栓与止血学重点实验室,南昌330002

出　　处：《中华检验医学杂志》2023年第10期987-991,共5页Chinese Journal of Laboratory Medicine

基　　金：国家重点研发计划(2022YFC2304601)。

摘　　要：凝血功能紊乱是脓毒症的常见危重并发症。新近研究发现,脓毒症时血管内皮细胞、血小板、白细胞和红细胞共同参与形成免疫血栓效应,临床可表现为以高凝血症为主的血栓形成和以低凝血症为主的出血。本文拟介绍脓毒症性凝血功能紊乱的发病机制、时相特征和实验室监测,以协助临床能够精准识别脓毒症性凝血功能紊乱。Coagulation disorder is a common and critical complication of sepsis.Recent studies have found that immunothrombosis is induced by the interaction of vascular endothelial cells,platelets,white blood cells and red blood cells in sepsis.Immunothrombosis can be clinically manifested as thrombosis dominated by hypercoagulability and hemorrhage with predominant hypocoagulability.This article will introduce the pathogenesis,temporal features,and laboratory monitoring of sepsis-induced coagulation disorders,in order to assist clinical personnel in accurately identifying septic coagulopathy.

关 键 词：脓毒症 凝血功能紊乱 监测 

分 类 号：R459.7[医药卫生—急诊医学]