无机离子聚合及其对材料和生物医学的变革  

Revolution in materials science and biomedicine via inorganic ionic polymerization

作　　者：方威风 颜禄淼 刘昭明[1] 唐睿康[1] FANG WeiFeng;YAN LuMiao;LIU ZhaoMing;TANG RuiKang(Department of Chemistry,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《中国科学：技术科学》2023年第10期1625-1638,共14页Scientia Sinica(Technologica)

基　　金：中央高校基本科研业务费(编号:226-2022-00022,2021FZZX001-04);国家自然科学基金(批准号:22022511)资助项目。

摘　　要：无机物由于其不同于有机高分子的合成方式,限制了其在诸多工程材料方面的应用.通过借鉴高分子化学中的封端策略,制备了系列类似高分子单体的无机离子寡聚体,实现其可控的聚合与交联,称为“无机离子聚合”.无机离子聚合实现了“像制备高分子一样制备无机物”,发展出无机可塑制备新方法及有机-无机共聚物、仿生有机-无机复合结构材料和柔性矿物塑料等新型工程材料.基于无机离子聚合及新型工程材料研发的基础,进一步发展出生物硬组织的修复新方法,包括牙釉质的再生、牙本质与骨的仿生再修复.无机离子聚合与交联反应体系的提出实现了无机化学合成的基础理论突破,衍生出新型工程材料以及生物医学研究体系的创新,将为医工交叉领域的新突破提供助力.The use of inorganic substances as engineering materials is limited due to their distinct synthetic behavior compared with organic polymers.Drawing inspiration from the end-capping method in polymer chemistry,a series of inorganic ionic oligomers,similar to monomers,are prepared for controllable polymerization and crosslinking.This process is called“inorganic ionic polymerization”.Inorganic ionic polymerization achieves“the preparation of inorganic substances in a manner akin to making polymers”.This process creates new ways for the malleable construction of inorganic materials and new engineering materials such as organic-inorganic copolymers,biomimetic organic-inorganic structural materials,and flexible mineral plastics.Inorganic ion polymerization and newly developed engineering materials lead to innovative strategies for the biomimetic regeneration of hard tissues,such as tooth enamel regeneration,biomimetic dentine,and bone remineralization.The proposal of inorganic ion polymerization and crosslinking reaction systems has achieved a breakthrough in the fundamental understanding of inorganic chemistry.It inspires the development of new engineering materials and biomedicine,providing breakthroughs in the interdisciplinary field of medicine and engineering.

关 键 词：无机离子聚合 无机离子寡聚体 仿生制备 力学材料 硬组织修复 

分 类 号：R318[医药卫生—生物医学工程] TB32[医药卫生—基础医学]