^(99)Tc^(m)-DTPA SPECT/CT眼眶显像在甲状腺相关性眼病诊疗中的应用进展  

Application advances of orbital ^(99)Tc^(m)-DTPA SPECT/CT in the diagnosis and treatment of thyroid-associated ophthalmopathy

作　　者：张瑞琪 闫春芳 孙斌 Zhang Ruiqi;Yan Chunfang;Sun Bin(First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;Department of Orbital Ophthalmology,Shanxi Eye Hospital,Taiyuan 030002,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西省眼科医院眼眶眼肿瘤科,太原030002

出　　处：《国际放射医学核医学杂志》2023年第9期573-578,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：山西省重大科技攻关专项(2020XM07)。

摘　　要：甲状腺相关性眼病(TAO)对患者的生活质量、心理健康以及社会经济都造成了严重的负面影响,在该病的早期活动期进行治疗的效果较好,目前该病的活动性分期主要采用临床活动性评分(CAS),其存在较多不足之处。近年来,^(99)Tc^(m)-二亚乙基三胺五乙酸(DTPA)SPECT/CT眼眶显像在TAO的早期诊断、治疗和随访中都显示出重要价值,其可以与CAS互相补充,应用前景广阔。笔者总结了目前该领域的研究进展,提出未来需要更多的研究以期建立标准化的采集和结果分析共识,进一步研究一种新的TAO筛选工具,将^(99)Tc^(m)-DTPA SPECT/CT眼眶显像与人工智能技术相结合,以便更加精准便捷地指导临床。Thyroid-associated ophthalmopathy(TAO)leads a significant negative impact on patients'quality of life,mental health and community economy.Treatment in the early active stage of the disease will achieve better efficacy.At present clinical activity score(CAS)is the mainly method of judging disease activity,but it has many shortcomings.Recent studies have suggested that ^(99)Tc^(m)diethylene triamine pentaacetic acid(DTPA)orbital SPECT/CT shows important value in the early diagnosis,treatment and follow-up of TAO.It can complement with CAS and has a broad application prospect.The authors summarize the current research progress in this field and highlight the need for more research to establish a standardized consensus on collection method and result analysis.Investigating a new tool to judge disease activity which can combine ^(99)Tc^(m)-DTPA orbital SPECT/CT with the artificial intelligence will more accurately and conveniently guide the clinical practice.

关 键 词：GRAVES眼病 99M锝五乙酸盐 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 眼眶 

分 类 号：R581[医药卫生—内分泌] R771.3[医药卫生—内科学] R817.4[医药卫生—临床医学]